Raw synthesis and mitochondrial function postischemic mitochondria diseases related to the lack or for use in new compd. 11β-hydroxysteroid
The present invention provides novel compounds of 112-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.
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Paragraph 0249
(2016/10/08)
Facile, High-Yield Synthesis of Spiro C-17 Steroidal Oxetan-3'-ones
The facile, high-yield conversion of C-17 α-keto mesylates of glucocorticoids to spiro C-17 oxetan-3'-ones is described.This reaction, involving treatment with strong base (KOH, NaOMe, or KO-t-Bu) in EtOH or THF, represents a major improvement for the pre
Pons, Michel,Simons, S. Stoney
p. 3262 - 3264
(2007/10/02)
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