77826-00-7

Usage

Uses

Used in Pharmaceutical Industry:
(11beta)-11-hydroxy-17,21-epoxypregn-4-ene-3,20-dione is used as an anti-inflammatory and immunosuppressive drug for treating conditions such as allergies, asthma, rheumatoid arthritis, and inflammatory bowel diseases. Its potent properties help reduce inflammation and suppress the immune system, providing relief from these conditions.
However, it is important to note that (11beta)-11-hydroxy-17,21-epoxypregn-4-ene-3,20-dione also comes with potential side effects, including weight gain, fluid retention, and increased susceptibility to infections. Therefore, its use should always be under the supervision of a healthcare professional to ensure safe and effective treatment.

Upstream product

• 33767-06-5 11β,17α-dihydroxy-21-iodopregn-4-ene-3,20-dione 
• 6677-96-9 11β,7α-dihydroxy-21-<(methylsulfonyl)oxy>pregn-4-ene-3,20-dione 
• 50-23-7 HYDROCORTISONE 
• 124-63-0 methanesulfonyl chloride 

Relevant academic research and scientific papers

Raw synthesis and mitochondrial function postischemic mitochondria diseases related to the lack or for use in new compd. 11β-hydroxysteroid

The present invention provides novel compounds of 112-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.

Facile, High-Yield Synthesis of Spiro C-17 Steroidal Oxetan-3'-ones

The facile, high-yield conversion of C-17 α-keto mesylates of glucocorticoids to spiro C-17 oxetan-3'-ones is described.This reaction, involving treatment with strong base (KOH, NaOMe, or KO-t-Bu) in EtOH or THF, represents a major improvement for the pre