- Efficient aerobic oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines
-
4-Substituted dihydropyrimidinones and dihydropyrimidines were first efficient aerobic oxidized to the corresponding pyrimidinones and pyrimidines, respectively, in high yields by molecular oxygen in the presence of catalytic amount of N-hydroxyphthalimid
- Han, Bing,Han, Run-Feng,Ren, Yu-Wei,Duan, Xiao-Yong,Xu, Yi-Chuan,Zhang, Wei
-
supporting information; experimental part
p. 5615 - 5620
(2011/08/09)
-
- PYRIMIDINE DERIVATIVES AS OREXIN RECEPTORS ANTAGONISTS
-
The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I)-wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different he
- -
-
Page/Page column 28
(2008/06/13)
-
- Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines
-
(Chemical Equation Presented) A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO 3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.
- Yamamoto, Kana,Chen, Ye Grace,Buono, Frederic G.
-
p. 4673 - 4676
(2007/10/03)
-
- Synthesis, antiviral (HSV-1) and antimycotic activities of ethyl or methyl 2,4-disubstituted 5-pyrimidinecarboxylates, 2,4-disubstituted 5-pyrimidinecarboxylic acids and 2,4-disubstituted pyrimidines
-
The synthesis of ethyl or methyl 4-substituted or unsubstituted 2-methylthio-5-pyrimidinecarboxylates 3 a-i and 8 o mainly by reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with 2-methylisothiourea is described. Also some ethyl 2-sub
- Sansebastiano,Mosti,Menozzi,Schenone,Muratore,Petta,Debbia,Pesce Schito,Schito
-
p. 335 - 355
(2007/10/02)
-
- An Improved General Synthesis of 4-Aryl-5-pyrimidinecarboxylates
-
We wish to report an improved, general synthesis of 4-aryl-5-pyrimidinecarboxylates 1.Two different routes have previously been reported for the synthesis of examples of this class of pyrimidine carboxylates.The parent compound, ethyl 4-phenyl-5-pyrimidinecarboxylate was prepared in low yield by the reaction of s-triazine with ethyl benzoyl acetate.In addition, the enol ether β-ketoaldehyde synthon, ethyl 2-benzoyl-3-ethoxy-2-propenoate, was reported to give 1a in modest yield when reacted with guanidine (2).
- Breaux, Eves J.,Zwikelmaier, Kurt E.
-
p. 183 - 184
(2007/10/02)
-