77995-06-3

Upstream product

• 75-91-2 tert.-butylhydroperoxide 
• 14527-26-5 2-methylisothiourea sulphate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 78-84-2 isobutyraldehyde 
• 867-44-7 S-Methylisothiourea sulfate 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 53114-57-1 S-methylisothiourea hydrochloride 

Downstream Products

• 149771-15-3 2-Methylsulfanyl-4-phenyl-pyrimidine-5-carboxylic acid 
• 56734-10-2 2-(methylsulfanyl)-4-phenylpyrimidine 

Relevant academic research and scientific papers

Efficient aerobic oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines

4-Substituted dihydropyrimidinones and dihydropyrimidines were first efficient aerobic oxidized to the corresponding pyrimidinones and pyrimidines, respectively, in high yields by molecular oxygen in the presence of catalytic amount of N-hydroxyphthalimid

PYRIMIDINE DERIVATIVES AS OREXIN RECEPTORS ANTAGONISTS

The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I)-wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different he

Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines

(Chemical Equation Presented) A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO 3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.

Synthesis, antiviral (HSV-1) and antimycotic activities of ethyl or methyl 2,4-disubstituted 5-pyrimidinecarboxylates, 2,4-disubstituted 5-pyrimidinecarboxylic acids and 2,4-disubstituted pyrimidines

The synthesis of ethyl or methyl 4-substituted or unsubstituted 2-methylthio-5-pyrimidinecarboxylates 3 a-i and 8 o mainly by reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with 2-methylisothiourea is described. Also some ethyl 2-sub

An Improved General Synthesis of 4-Aryl-5-pyrimidinecarboxylates

We wish to report an improved, general synthesis of 4-aryl-5-pyrimidinecarboxylates 1.Two different routes have previously been reported for the synthesis of examples of this class of pyrimidine carboxylates.The parent compound, ethyl 4-phenyl-5-pyrimidinecarboxylate was prepared in low yield by the reaction of s-triazine with ethyl benzoyl acetate.In addition, the enol ether β-ketoaldehyde synthon, ethyl 2-benzoyl-3-ethoxy-2-propenoate, was reported to give 1a in modest yield when reacted with guanidine (2).