- Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential
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The P2Y14 nucleotide receptor, a subtype of P2Y receptors, is implicated in many human inflammatory diseases. Based on the identification of favorable residues of two screening hits in the almost symmetrical P2Y14 binding domain, we
- Zhou, Mengze,Wang, Weiwei,Wang, Zhongkui,Wang, Yilin,Zhu, Yifan,Lin, Zhiqian,Tian, Sheng,Huang, Yuan,Hu, Qinghua,Li, Huanqiu
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- Novel compound and organic light emitting device comprising the same
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The present invention provides a novel compound and an organic light emitting device including the same.
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Paragraph 0308; 0314-0317
(2021/09/07)
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- Novel compound and organic light emitting device comprising the same
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The present invention provides a novel compound and an organic light emitting device using the same.
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Paragraph 0194; 0220-0223
(2021/09/14)
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- NOVEL COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME
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The present invention provides a novel compound represented by chemical formula 1 and an organic light emitting device using the same. The compound may improve lifespan characteristics of the organic light emitting device.
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Paragraph 0192-0193; 0198-0199
(2021/03/09)
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- Benzofuran small-molecule P2Y receptor inhibitor and preparation and application thereof
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The invention discloses a benzofuran derivative shown in a formula (I) and a preparation method and application thereof. The experimental results show that the benzofuran derivative has good P2Y inhibitory activity and anti-inflammatory activity, and
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- New anti-cancer strategy to suppress colorectal cancer growth through inhibition of atg4b and lysosome function
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Autophagy inhibition has been proposed to be a potential therapeutic strategy for cancer, however, few autophagy inhibitors have been developed. Recent studies have indicated that lysosome and autophagy related 4B cysteine peptidase (ATG4B) are two promis
- Fu, Yuanyuan,Gu, Qianqian,Han, Fanghai,Hong, Liang,Huang, Zhiying,Li, Min,Luo, Li,Luo, Yuping,Xia, Fan,Xu, Jiecheng,Yin, Xiao-Ming
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- Autophagy inhibitor and application thereof
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The invention belongs to the technical field of medicines, and discloses an autophagy inhibitor and application thereof. The general structural formula of the inhibitor is as shown in a formula I. Inthe formula I, R1 is monosubstituted; R2 is monosubstituted, disubstituted or polysubstituted; X is one selected from a group consisting of O, S, Se, NH, NR3, P(O)R3, CH2, CHR and CR3R4; and substituent groups R1, R2, R3 and R4 are independently selected from H, halogen, -CF3, -CN, -NO2, -OH, -NH2 and the like. The autophagy inhibitor can effectively inhibit the activity of ATG4B and inhibit the function of lysosome so as to block the process of cell autophagy, and can be used as a bifunctional autophagy inhibitor; and meanwhile, the autophagy inhibitor has good anti-tumor cell proliferation activity and can be used for preparing anti-tumor drugs.
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Paragraph 0029-0033
(2020/08/30)
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- Discovery of novel N-(5-(tert-butyl)isoxazol-3-yl)-N′-phenylurea analogs as potent FLT3 inhibitors and evaluation of their activity against acute myeloid leukemia in vitro and in vivo
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FLT3 inhibitors have been explored as a viable therapy for acute myeloid leukemia (AML). However, the clinical outcomes of these FLT3 inhibitors were underwhelming except AC220. Therefore, the development of novel FLT3 inhibitors with high potency against
- Xu, Ying,Wang, Ning-Yu,Song, Xue-Jiao,Lei, Qian,Ye, Ting-Hong,You, Xin-Yu,Zuo, Wei-Qiong,Xia, Yong,Zhang, Li-Dan,Yu, Luo-Ting
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p. 4333 - 4343
(2015/08/03)
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- Palladium nanoparticles catalyzed synthesis of benzofurans by a domino approach
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Abstract Palladium nanoparticles (PdNPs) were used as a catalyst for the one-pot synthesis of a variety of benzofurans by Sonogashira cross-coupling reactions under ambient conditions. The catalyst could be recycled without significant loss in its activity.
- Mandali, Pavan Kumar,Chand, Dillip Kumar
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p. 1661 - 1668
(2015/06/02)
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- Transforming Suzuki-Miyaura cross-couplings of MIDA boronates into a green technology: No organic solvents
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New technology has been developed that enables Suzuki-Miyaura couplings involving widely utilized MIDA boronates to be run in water as the only medium, mainly at room temperature. The protocol is such that no organic solvent is involved at any stage; from the reaction through to product isolation. Hence, using the E factor scale as a measure of greenness, the values for these cross-couplings approach zero.
- Isley, Nicholas A.,Gallou, Fabrice,Lipshutz, Bruce H.
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supporting information
p. 17707 - 17710
(2014/01/06)
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- Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
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A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or brom
- Yang, Xiao-Dong,Wan, Wei-Chao,Deng, Xiao-Yan,Li, Yan,Yang, Li-Juan,Li, Liang,Zhang, Hong-Bin
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p. 2726 - 2729
(2012/05/20)
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- NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR
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The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
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Page/Page column 195
(2008/12/08)
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- Development and Application of Organic Reagents for Analysis. VI. Synthesis and Fluorescence Spectral Properties of 2-(4-Substituted phenyl)benzofurans
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A synthesis of fifteen kinds of 2-(4-substituted phenyl)benzofurans (4n) was carried out and their fluorescence spectral properties were investigated concerning their applicability as organic reagents for analyses.
- Akiyama, Shuzo,Akimoto, Hiroyuki,Nakatsuji, Shin'ichi,Nakashima, Kenichiro
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p. 2192 - 2196
(2007/10/02)
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