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CAS

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78420-14-1

[S-(R,R)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid, commonly known as Ramipril, is a pharmaceutical compound that belongs to the class of angiotensin-converting enzyme (ACE) inhibitors. It is characterized by its ability to relax blood vessels and reduce the workload on the heart, making it a valuable treatment for various cardiovascular conditions.

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  • 78420-14-1 Structure

  • Basic information

    1. Product Name: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid
    2. Synonyms: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid;(4S)-3-[(3S)-3-Cyclohexyl-3-hydroxypropyl]-2,5-dioxo-4-imidazolidineheptanoic acid
    3. CAS NO:78420-14-1
    4. Molecular Formula: C19H32N2O5
    5. Molecular Weight: 368.46778
    6. EINECS: 278-904-1
    7. Product Categories: N/A
    8. Mol File: 78420-14-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid(78420-14-1)
    11. EPA Substance Registry System: [S-(R*,R*)]-3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid(78420-14-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 78420-14-1(Hazardous Substances Data)

78420-14-1 Usage

Uses

Used in Pharmaceutical Industry:
Ramipril is used as an ACE inhibitor for the treatment of high blood pressure, heart failure, and diabetic kidney disease. Its application is based on its ability to relax blood vessels and reduce the workload on the heart, which helps in managing these conditions effectively.
Used in Cardiovascular Applications:
In the cardiovascular field, Ramipril is used to improve blood flow and reduce the strain on the heart. This is achieved by inhibiting the angiotensin-converting enzyme, which in turn lowers blood pressure and decreases the risk of heart-related complications.

Check Digit Verification of cas no

The CAS Registry Mumber 78420-14-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,4,2 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 78420-14:
(7*7)+(6*8)+(5*4)+(4*2)+(3*0)+(2*1)+(1*4)=131
131 % 10 = 1
So 78420-14-1 is a valid CAS Registry Number.

78420-14-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (5S)-5-(6-carboxyhexyl)-1-<(3S)-3-cyclohexyl-3-hydroxypropyl>hydantoin

1.2 Other means of identification

Product number -
Other names (5S)-5-(6-carboxyhexyl)-1-((3S)-3-cyclohexyl-3-hydroxypropyl)hydantoin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78420-14-1 SDS

78420-14-1Relevant articles and documents

Heterocyclic Prostaglandin Analogues. Part 3. The Relationship of Configuration to Biological Activity for Some Hydantoin Prostanglandin Analogues

Brockwell, Michael A.,Caldwell, A. Gordon,Whittaker, Norman,Begley, Michael J.

, p. 706 - 711 (2007/10/02)

The enantiomers of the two diastereomers of 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin have been synthesised.Potent inhibition of platelet aggregation in this series is associated with the configuration corresponding to that in the natural inhibitors, such as prostaglandins E1 and D2.

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