Novel Mannich Reaction of 8-Acetyl-7-hydroxy-4-methylcoumarin with 1-Arylpiperazines
8-Acetyl-7-hydroxy-4-methylcoumarin (I) reacts with 1-arylpiperazines in the presence of excess paraformaldehyde to yield 4-methyl-9-(4-aryl-1-piperazinylmethyl)-2H,10H-8,9-dihydrobenzodipyran-2,10-diones, instead of the Mannich bases (II) or (III).The compounds show action on smooth muscles and act as agonists to the heart muscle receptors.
Samant, S. D.,Deodhar, K. D.,Kulkarni, R. A.
p. 215 - 217
(2007/10/02)
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