Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group
An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.
Yang, Yiqing,Lin, Yun,Rao, Yu
supporting information; experimental part
p. 2874 - 2877
(2012/07/28)
ANESTHETIC COMPOUNDS
The invention provides novel phenolic ester local anesthetic compounds. The invention also provides pharmaceutical compositions that include such compounds as well as methods for making such compounds and compositions and methods for using such compounds
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Page/Page column 20-21
(2009/08/16)
ANESTHETIC COMPOUNDS
In one embodiment the invention provides novel compounds of Formula (I) as well as prodrugs, salts, hydrates, solvates and N-oxides thereof. The invention also provides pharmaceutical compositions that include such compounds as well as methods for making and methods for using such compounds in medical therapy.
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Page/Page column 36; 40; 44; 48
(2008/06/13)
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