cas 79154-57-7, N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine

Articles about 79154-57-7Total 19 be found

SYNTHESIS OF 3'N NUCLEOSIDES THROUGH OXIME INTERMEDIATES AND RELATED COMPOUNDS
Provided herein are novel synthetic routes to amines through an oxime intermediate, e.g., 3'-N nucleosides and novel and intermediate compounds produced during these synthetic procedures.
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Paragraph 0147

(2021/09/26)

LIGAND-2'-MODIFIED NUCLEIC ACIDS, SYNTHESIS THEREOF AND INTERMEDIATE COMPOUNDS THEREOF
The present invention relates to methods for synthesizing compounds useful as potent and stable RNA interference agents, derivatives thereof, and intermediates thereto.
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Paragraph 00338; 00346-00347

(2021/03/05)

BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
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Paragraph 00490

(2020/08/28)

BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
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Paragraph 00503

(2019/03/05)

COMPOUNDS
Disclosed herein are 2'-spiro-nucleosides of formula I and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus. Formula (I), where z is a four-or five-membered ring selected from among radicals a-o represented b
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(2012/06/16)

An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method
A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat
Efimov,Aralov,Fedunin,Klykov,Chakhmakhcheva
scheme or table
p. 250 - 253
(2010/04/06)

Assessment of 4-nitrogenated benzyloxymethyl groups for 2′-Hydroxyl protection in solid-phase RNA synthesis
The search for a 2′-OH protecting group that would impart ribonucleoside phosphoramidites with coupling kinetics and coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites led to an assessment of 2′-0-(4-nitrogenated benzyloxy)m
Cieslak, Jacek,Kauffman, Jon S.,Kolodziejski, Michelle J.,Lloyd, John R.,Beaucage, Serge L.
p. 671 - 674
(2008/02/05)

Synthesis of fluorescein-labeled oligonucleotides bearing a tag in position 2′ of modified adenosine and arabinoadenosine
Oligonucleotide conjugates containing fluorescein residues in the sugar-phosphate back-bone were synthesized by the standard solid-phase phosphoramidite method using phosphor-amidites of 9-[2-deoxy-5-O-(4,4′- dimethoxytrityl)-2-methoxalylamino-β-D-ribofur
Vasileva,Krasnousova,Donina,Abramova,Zhdanova,Kovalenko,Silnikov
p. 1677 - 1683
(2008/02/09)

Synthesis of RNA using 2′-O-DTM protection
tert-Butyldithiomethyl (DTM), a novel hydroxyl protecting group, cleavable under reductive conditions, was developed and applied for the protection of 2′-OH during solid-phase RNA synthesis. This function is compatible with all standard protecting groups used in oligonucleotide synthesis, and allows for fast and high-yield synthesis of RNA. Oligonucleotides containing the 2′-O-DTM groups can be easily deprotected under the mildest possible aqueous and homogeneous conditions. The preserved 5′-O-DMTr function can be used for high-throughput cartridge RNA purification. Copyright
Semenyuk, Andrey,Foeldesi, Andras,Johansson, Tommy,Estmer-Nilsson, Camilla,Blomgren, Peter,Braennvall, Mathias,Kirsebom, Leif A.,Kwiatkowski, Marek
p. 12356 - 12357
(2007/10/03)

Synthesis and structural characterization of diastereomeric isomers of RNA trimer adenylyl(3′-5′)adenylyl(3′-5′)adenosine
We have synthesized the diastereomeric isomers of adenylyl(3′- 5′)adenylyl(3′-5′)adenosine (ApApA), and investigated their helical structures and hybridization properties with d-poly(U) by circular dichroism (CD) and UV melting experiments. The configurat
Urata, Hidehito,Hara, Hisafumi,Hirata, Yoshihiro,Ohmoto, Norihiko,Akagi, Masao
p. 2908 - 2917
(2007/10/03)

The PdCl2/R3SiH system for the silylation of nucleosides
Convenient syntheses of TIPDS-Cl2 and TBDMS-Br from the corresponding hydrides were obtained by using catalytic PdCl2 and CCl4 or CH2Br2, respectively. These systems can be successfully applied in tandem procedures for improved silylation of nucleosides.
Ferreri,Costantino,Romeo,Chatgilialoglu
p. 1197 - 1200
(2007/10/03)

Synthesis and properties of modified oligodeoxyribonucleotides containing 9-(2-amino-2-deoxy-β-D-arabinofuranosyl)adenine
The synthesis of modified oligodeoxyribonucleotides containing 2'- amino-2'-deoxyarabinoadenosine residues (aA(n)) was carried out by means of the standard phosphoramidite chemistry. A high reactivity of such compounds to electrophilic reagents was shown.
Zubin, Eugene M.,Antsypovich, Sergey I.,Oretskaya, Tatiana S.,Romanova, Elena A.,Volkov, Eugene M.,Tashlitsky, Vadim N.,Dolinnaya, Nina G.,Shabarova, Zoe A.
p. 425 - 440
(2007/10/03)

Synthesis of modified oligodeoxyribonucleotides containing 9-(2′-amino-2′-deoxy-β-D-arabinofuranosyl)adenine
A method for preparing a modified derivative of 2′-amino-2′-deoxy-arabino-adenosine ready for directed insertion into an oligonucleotide chain during solid-phase synthesis was elaborated. A series of the title oligonucleotides (6-25-mers) containing a 2′-
Zubin,Antsypovich,Oretskaya,Romanova,Volkov,Tashlitskii,Shabarova
p. 730 - 736
(2007/10/03)

2'-O-methylthiomethyl modifications in hammerhead ribozymes
The synthesis of all four phosphoramidites of 2'-O-methylthiomethyl ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described.
Karpeisky, Alexander,Gonzalez, Carolyn,Burgin, Alex B.,Usman, Nassim,Beigelman, Leonid
p. 955 - 958
(2007/10/03)

Nucleotides. Part XLII. The 2-dansylethoxycarbonyl (=2-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl]}ethoxycarbonyl; Dnseoc) group for protection of the 5'-hydroxy function in oligoribonucleotide synthesis
The 2-dansylethoxycarbonyl (Dnseoc) group was employed for protection of the 5'-hydroxy function in oligoribonucleotide synthesis by the phosphoramidite approach using the acid-labile tetrahydro-4-methoxy-2H-pyran-4-yl (Thmp) group for 2'-protection. The
Bergmann,Pfleiderer
p. 481 - 501
(2007/10/02)

Synthesis of 2'-thioadenosine
Reaction between 5-N-benzoyl-9-adenine (12a), prepared from 9-(β-D-arabinofuranosyl)adenine, and 9-(4-methoxyphenyl)xanthene-9-thiol (AXT, 7b) in the pr
Marriott, Jonathan H.,Mottahedeh, Mina,Reese, Colin B.
p. 257 - 269
(2007/10/02)

Studies on transfer ribonucleic acids and related compounds. XLIV. A large-scale synthesis of the anticodon heptanucleotide of formyl-methionine transfer ribonucleic acid by using 2'-O-tetrahydrofuranylnucleosides.
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Ohtsuka,Ohkubo,Yamane,Ikehara
p. 1910 - 1916
(2007/10/02)

THE TETRAISOPROPYLDISILOXANE-1,3-DIYL: A VERSATILE PROTECTING GROUP FOR THE SYNTHESIS OF ADENYLYL-(2'->5')-ADENYLYL-(2'->5')-ADENOSINE (2-5A CORE).
A2'p5'A2'p5'A has been synthesised in large scale using 3',5'-tetraisopropyldisilyl-6-N-benzoyl adenosine as the starting material.
Gioeli, C.,Kwiatkowski, M.,Oeberg, B.,Chattopadhyaya, J. B.
p. 1741 - 1744
(2007/10/02)