79154-57-7

Usage

Uses

Used in Synthesis of Branched Oligoribonucleotides:
N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine is used as a key component in the synthesis of branched oligoribonucleotides. These branched structures are designed to mimic intronic lariat RNA intermediates, which play a crucial role in the process of RNA splicing. N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine's unique structure allows for the creation of these complex RNA mimics, which can be used for studying the mechanisms of RNA splicing and developing potential therapeutic strategies targeting this process.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine may be utilized as a starting material or intermediate in the development of new drugs targeting RNA-related diseases. Its unique chemical structure could potentially be exploited to design novel therapeutic agents that modulate RNA splicing or interact with specific RNA targets, offering new treatment options for various conditions.
Used in Research and Development:
N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine can also be employed in research and development settings, particularly in the fields of molecular biology, biochemistry, and biotechnology. Researchers may use N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine to study the interactions between RNA and various proteins or small molecules, as well as to develop new tools and techniques for manipulating RNA structures and functions.

Upstream product

• 98-88-4 benzoyl chloride 
• 118684-36-9 O^2;_,O3'_,O5'-tris-trimethylsilyl-N⁶-benzoyladenosine 
• 10457-15-5 O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine 
• 58-61-7 adenosine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 4546-55-8 N-benzoyladenosine 
• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 

Downstream Products

• 87865-81-4 N-{9-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(tetrahydro-furan-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide 
• 90191-58-5 N⁶-Benzoyl-3',5'-O-TIPDSi(OH)-P-methyl-P-thioadenylyl-(2'-5')-N⁶,N⁶,O^2',O^3'-tetrabenzoyladenosine 
• 90108-23-9 C₉₈H₁₁₉N₁₅O₂₃P₂S₂Si₄ 
• 114494-74-5 6-N-benzoyl-3',5'-O-(tetraisopropyl-1,3-disiloxane-1,3-diyl)-3'-O-phosphiteamidite 
• 114515-40-1 Dimethyl-phosphoramidous acid (2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester 9H-fluoren-9-ylmethyl ester 
• 100802-96-8 Chloromethyl-phosphonic acid mono-[(2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester 
• 115264-87-4 C₅₄H₆₆N₇O₁₆PSi₂ 
• 115288-13-6 C₆₂H₇₁N₁₀O₁₅PSi₂ 
• 121768-15-8 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate) 
• 99272-55-6 2'-O-(3-methoxy-1,5-dicarbomethoxypentanyl)-6-N-benzoyladenosine 
• 97997-64-3 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-6-N-benzoyladenosine 2'-phosphorodianilidate 
• 169687-74-5 N⁶-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]adenine 
• 139434-69-8 N-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1, 3-diyl)-2′-O-[(methylthio)methyl]adenosine 
• 100034-54-6 N-[9-((2R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide 

Relevant academic research and scientific papers

SYNTHESIS OF 3'N NUCLEOSIDES THROUGH OXIME INTERMEDIATES AND RELATED COMPOUNDS

Provided herein are novel synthetic routes to amines through an oxime intermediate, e.g., 3'-N nucleosides and novel and intermediate compounds produced during these synthetic procedures.

LIGAND-2'-MODIFIED NUCLEIC ACIDS, SYNTHESIS THEREOF AND INTERMEDIATE COMPOUNDS THEREOF

The present invention relates to methods for synthesizing compounds useful as potent and stable RNA interference agents, derivatives thereof, and intermediates thereto.

BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method

A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat

Assessment of 4-nitrogenated benzyloxymethyl groups for 2′-Hydroxyl protection in solid-phase RNA synthesis

The search for a 2′-OH protecting group that would impart ribonucleoside phosphoramidites with coupling kinetics and coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites led to an assessment of 2′-0-(4-nitrogenated benzyloxy)m

Synthesis of RNA using 2′-O-DTM protection

tert-Butyldithiomethyl (DTM), a novel hydroxyl protecting group, cleavable under reductive conditions, was developed and applied for the protection of 2′-OH during solid-phase RNA synthesis. This function is compatible with all standard protecting groups used in oligonucleotide synthesis, and allows for fast and high-yield synthesis of RNA. Oligonucleotides containing the 2′-O-DTM groups can be easily deprotected under the mildest possible aqueous and homogeneous conditions. The preserved 5′-O-DMTr function can be used for high-throughput cartridge RNA purification. Copyright

Synthesis of fluorescein-labeled oligonucleotides bearing a tag in position 2′ of modified adenosine and arabinoadenosine

Oligonucleotide conjugates containing fluorescein residues in the sugar-phosphate back-bone were synthesized by the standard solid-phase phosphoramidite method using phosphor-amidites of 9-[2-deoxy-5-O-(4,4′- dimethoxytrityl)-2-methoxalylamino-β-D-ribofur

Synthesis and structural characterization of diastereomeric isomers of RNA trimer adenylyl(3′-5′)adenylyl(3′-5′)adenosine

We have synthesized the diastereomeric isomers of adenylyl(3′- 5′)adenylyl(3′-5′)adenosine (ApApA), and investigated their helical structures and hybridization properties with d-poly(U) by circular dichroism (CD) and UV melting experiments. The configurat