79247-77-1

Basic information

• Product Name: 2-Thiazolamine, 5-bromo-4-methyl-, monohydrobromide
• CAS NO: 79247-77-1
• Molecular Formula: C4H5BrN2S.BrH
• Molecular Weight: 273.979
• Mol File: 79247-77-1.mol

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, 5-bromo-4-methyl-, monohydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, 5-bromo-4-methyl-, monohydrobromide(79247-77-1)
• EPA Substance Registry System: 2-Thiazolamine, 5-bromo-4-methyl-, monohydrobromide(79247-77-1)

Safety Data

• Hazardous Substances Data: 79247-77-1(Hazardous Substances Data)

Upstream product

• 1603-91-4 4-methylthiazol-2-ylamine 

Downstream Products

• 79247-78-2 2,5-dibromo-4-methylthiazole 
• 792915-59-4 acetic acid-[4-(2-amino-4-methyl-thiazole-5-sulfonyl)-anilide] 

Relevant articles and documents

Viral polymerase inhibitors

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein R1 is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR5, wherein R5 is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR5; D is N or CR5; each of Y1 and Y2 is independently O or S; Z is O, N, or NRz wherein Rz is H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R3 and R4 are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl or 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R3 and R4 are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R3 or R4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R7 is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R7 is covalently bonded to either of R3 or R4 to form a heterocycle; A is (C1-6) alkyl-CONHR8 wherein R8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.

An Infrared Study of Rotational Isomerism in Thiazole-2-carboxylates

A series of alkyl thiazole-2-carboxylates containing a range of substituents at the 4- and 5-positions has been prepared.Solutions of these esters (mostly new compounds) show well resolved doublets in the i.r.C=O region which arise from rotational isomers.The higher wavenumber components are assigned to the more polar carbonyl O,S-anti-s-trans-rotamers and the lower wavenumber components to the carbonyl O,S-syn-s-trans-forms.Small, but systematic, differences between the methyl esters are noted.