- Optically active 2-acylheteroaromatic chromane compound used in the preparation of the catalyst precursor, (by machine translation)
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PROBLEM TO BE SOLVED: To obtain an optically active 2-acyl chroman compound in a high yield.SOLUTION: The optically active 2-acyl chroman compound is obtained in a high yield with a high enantiomeric excess by the reaction of a keto phenol compound with hydroperoxide in the presence of an N-spiro C-asymmetric chiral quaternary ammonium iodide as a catalyst precursor.
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Paragraph 0049
(2018/02/28)
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- Synthesis and screening of novel vitamin e derivatives for anticancer functions
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α-TEA, RRR-α-tocopherol ether linked acetic acid, exhibits potent anticancer actions in vitro and in vivo; whereas, the parent molecule has no anticancer activity. In this study, we incorporated fluorine at the chroman head and/or ether linkage between the chroman head and phytyl tail of α-TEA as well as RRR-α-tocopherol to synthesize 6 vitamin E derivatives, and evaluated the anticancer actions in vitro for ability to induce cell death by apoptosis of human MCF-7 and MDA-MB-231 breast cancer cell lines and mouse mammary cancer cell line 66cl-4GFP. All derivatives, with the exception of compound 12, exhibited anticancer properties. The modified α-TEA ether-type phytyl group exhibited the highest pro-apoptotic activity in comparison with α-TEA as well as other vitamin E derivatives.
- Chen, Wenbin,Park, Sook Kyung,Yu, Weiping,Xiong, Ailian,Sanders, Bob G.,Kline, Kimberly
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- Tocopherol, tocotrienol, other chromane, and their side chain deriv. and method for using the same
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The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound having said structural formula.
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Page/Page column 25-26
(2008/06/13)
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- Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
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The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
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Page column 22
(2008/06/13)
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