79397-72-1

Upstream product

• 53101-49-8 (S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 
• 333-27-7 methyl trifluoromethanesulfonate 
• 1581709-96-7 4-hydroxy-2,3,6-trimethyl-5-[3-methyl-4-oxo-4-(1-phenyl-1H-imidazol-2-yl)butyl]phenyl 4-methylbenzenesulfonate 
• 1581710-02-2 (S)-2,5,7,8-tetramethyl-2-(1-phenyl-1H-imidazole-2-carbonyl)chroman-6-yl-4-methylbenzenesulfonate 
• 100-39-0 benzyl bromide 
• 70897-17-5 (S)-(+)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester 
• 100-44-7 benzyl chloride 

Downstream Products

• 69371-87-5 (S)-(-)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol 
• 1406-70-8 (2R,4'RS,8'RS)-α-tocopheryl acetate 
• 895518-38-4 vitamin E 
• 69400-39-1 (+) (S)-6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-carbaldhyde 

Relevant academic research and scientific papers

Optically active 2-acylheteroaromatic chromane compound used in the preparation of the catalyst precursor, (by machine translation)

PROBLEM TO BE SOLVED: To obtain an optically active 2-acyl chroman compound in a high yield.SOLUTION: The optically active 2-acyl chroman compound is obtained in a high yield with a high enantiomeric excess by the reaction of a keto phenol compound with hydroperoxide in the presence of an N-spiro C-asymmetric chiral quaternary ammonium iodide as a catalyst precursor.

Synthesis and screening of novel vitamin e derivatives for anticancer functions

α-TEA, RRR-α-tocopherol ether linked acetic acid, exhibits potent anticancer actions in vitro and in vivo; whereas, the parent molecule has no anticancer activity. In this study, we incorporated fluorine at the chroman head and/or ether linkage between the chroman head and phytyl tail of α-TEA as well as RRR-α-tocopherol to synthesize 6 vitamin E derivatives, and evaluated the anticancer actions in vitro for ability to induce cell death by apoptosis of human MCF-7 and MDA-MB-231 breast cancer cell lines and mouse mammary cancer cell line 66cl-4GFP. All derivatives, with the exception of compound 12, exhibited anticancer properties. The modified α-TEA ether-type phytyl group exhibited the highest pro-apoptotic activity in comparison with α-TEA as well as other vitamin E derivatives.

Tocopherol, tocotrienol, other chromane, and their side chain deriv. and method for using the same

The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound having said structural formula.

Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen o r sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.