- One-pot and novel route for the synthesis of 4-substituted-1,2,4- triazolidine-3,5-diones
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The efficient and one-pot synthesis of 4-substituted-1,2,4-triazolidin-3,5- dione derivatives (4-substituted urazoles) via combination of triphosgene, substituted anilines, and ethyl carbazate in the presence of cesium carbonate is presented.
- Ghorbani-Choghamarani, Arash,Nikoorazm, Mohsen,Azadi, Gouhar
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p. 451 - 454
(2014/03/21)
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- A novel one-pot synthesis of 4-substituted 1,2,4-triazolidine-3,5-diones
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A simple and one-pot pathway for the preparation of 4-substituted phenyl derivatives of triazolidindiones (urazoles), starting from aniline derivatives is reported. In these methods aniline derivatives were reacted with ethyl chloroformate, to give the corresponding carbamate derivatives. In the second step semicarbazide derivatives were prepared from these carbamates by reaction with ethyl carbazide. The cyclization reactions of the corresponding semicarbazides furnished triazolidindiones. All reactions were performed in one vessel without the isolation of reaction intermediates, such as carbamates and semicarbazides, and the final products were isolated in good yields. Georg Thieme Verlag Stuttgart.
- Mallakpour, Shadpour,Rafiee, Zahra
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p. 1255 - 1256
(2007/12/26)
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- Novel and efficient synthesis of 4-substituted-1,2,4-triazolidine-3,5- diones from anilines
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A simple and efficient three-step synthetic procedure for the preparation of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles), starting from anilines, has been developed. In this method, aniline derivatives were reacted with 4-nitrophenyl chloroformate to provide corresponding carbamate derivatives. In the second step, semicarbazide derivatives were prepared from these carbamates by reaction with ethyl carbazate. The cyclization reaction of corresponding semicarbazides furnished 1,2,4-triazolidindiones in high yields. Copyright Taylor & Francis Group, LLC.
- Mallakpour, Shadpour,Rafiee, Zahra
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p. 1927 - 1934
(2008/02/04)
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- Proton-Transfer Chemistry of Urazoles and Related Imides, Amides, and Diacyl Hydrazides
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Equilibrium acidity constants have been determined for 1,2,4-triazolidine-3,5-dione (urazole), several substituted urazoles, and other related acids, in both dimethyl sulfoxide (DMSO) and aqueous solution.In DMSO, urazole has a pKa of 13.1.In w
- Bausch, M. J.,David, B.,Dobrowolski, P.,Guadalupe-Fasano, C.,Gostowski, R.,et al.
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p. 5643 - 5651
(2007/10/02)
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