- 3-ethyl-4-fluorobenzonitrile preparation method
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The invention relates to a 3-ethyl-4-fluorobenzonitrile preparation method, a compound (II) has a coupling reaction with an ethyl coupling reagent in a solvent under the existence of a catalyst to obtain a compound (I), wherein X is chlorine, bromine, iodine, trifluorosulfonate, and methanesulfonate. The preparation method has the advantages that the materials are easy to get, the operation is safe and simple, the product purity is high, and the cost is low.
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Page/Page column 0043-0048
(2018/11/03)
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- Preparation of 3-bromo-4-fluorobenzaldehyde and its acetals
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A process for the preparation of a 3-bromo-4-fluorobenzaldehyde acetal of the formula STR1 in which R1 is methyl or ethyl, which comprises reacting a 3-bromo-4-fluoro-benzoic acid halide with ammonia to form 3-bromo-4-fluoro-benzoic acid amide, dehydrating said amide to form 3-bromo-4-fluoro-benzonitrile, reacting the nitrile with formic acid in the presence of a catalyst at a temperature between about 0° and 150° C. to form 3-bromo-4-fluorobenzaldehyde, and reacting said aldehyde with R1 OH or a derivative thereof capable of forming an acetal. The amide and nitrile are new compounds. The acetals are known intermediates in the synthesis of pyrethroid-like insecticides.
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