79630-23-2

Usage

Chemical Properties

WHITE CRYSTALLINE LOW MELTING SOLID

InChI:InChI=1/C2H5F2N.ClH/c3-2(4)1-5;/h2H,1,5H2;1H

Upstream product

• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 455-85-6 methyl 3-bromo-4-fluorobenzamide 

Downstream Products

• 179896-05-0 6-(3-Cyano-6-fluorophenyl)-1,2-dihydro-2,2,4-trimethylquinoline 
• 1325219-94-0 3-bromo-4-(2-iodophenoxy)benzonitrile 
• 1325219-95-1 3-bromo-4-(2-((trimethylsilyl)ethynyl)phenoxy)benzonitrile 
• 1007-16-5 3-bromo-4-fluorobenzoic acid 
• 869299-63-8 3-ethyl-4-fluorobenzonitrile 
• 863868-29-5 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 

Relevant academic research and scientific papers

3-ethyl-4-fluorobenzonitrile preparation method

The invention relates to a 3-ethyl-4-fluorobenzonitrile preparation method, a compound (II) has a coupling reaction with an ethyl coupling reagent in a solvent under the existence of a catalyst to obtain a compound (I), wherein X is chlorine, bromine, iodine, trifluorosulfonate, and methanesulfonate. The preparation method has the advantages that the materials are easy to get, the operation is safe and simple, the product purity is high, and the cost is low.

Preparation of 3-bromo-4-fluorobenzaldehyde and its acetals

A process for the preparation of a 3-bromo-4-fluorobenzaldehyde acetal of the formula STR1 in which R1 is methyl or ethyl, which comprises reacting a 3-bromo-4-fluoro-benzoic acid halide with ammonia to form 3-bromo-4-fluoro-benzoic acid amide, dehydrating said amide to form 3-bromo-4-fluoro-benzonitrile, reacting the nitrile with formic acid in the presence of a catalyst at a temperature between about 0° and 150° C. to form 3-bromo-4-fluorobenzaldehyde, and reacting said aldehyde with R1 OH or a derivative thereof capable of forming an acetal. The amide and nitrile are new compounds. The acetals are known intermediates in the synthesis of pyrethroid-like insecticides.