79784-36-4

Basic information

• Product Name: 2,4-DIFLUOROPHENYLGLYOXAL HYDRATE
• Synonyms: 2,4-DIFLUOROPHENYLGLYOXAL HYDRATE;2,4-DIFLUOROPHENYLGLYOXAL MONOHYDRATE;2-(2,4-DIFLUOROPHENYL)-2-OXOACETALDEHYDE;2,4-DIFLUOROPHENYLGLYOXAL HYDRATE , DRY WT. BASIS;2,4-Difluorophenylglyoxal hydrate, 95%, dry wt. basis;2,4-Difluorophenylglyoxal
• CAS NO: 79784-36-4
• Molecular Formula: C₈H₄F₂O₂
• Molecular Weight: 188.13
• Mol File: 79784-36-4.mol

Chemical Properties

• Melting Point: 51-54°C
• Boiling Point: 219.2°C at 760 mmHg
• Flash Point: 82.4°C
• Appearance: /
• Vapor Pressure: 0.121mmHg at 25°C
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in water.
• BRN: 4387465
• CAS DataBase Reference: 2,4-DIFLUOROPHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROPHENYLGLYOXAL HYDRATE(79784-36-4)
• EPA Substance Registry System: 2,4-DIFLUOROPHENYLGLYOXAL HYDRATE(79784-36-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 79784-36-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIFLUOROPHENYLGLYOXAL HYDRATE is used as a pharmaceutical intermediate for the synthesis of biologically active 1,2,4-triazine derivatives. These derivatives possess a wide range of pharmacological properties, making them valuable in the development of new drugs for various therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 2,4-DIFLUOROPHENYLGLYOXAL HYDRATE is utilized as a key building block for the preparation of various chemical compounds. Its reactivity and functional groups allow for the formation of diverse molecular structures, which can be further modified to achieve desired properties and applications.

InChI:InChI=1/C8H4F2O2.H2O/c9-5-1-2-6(7(10)3-5)8(12)4-11;/h1-4H;1H2

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 364-83-0 2',4'-difluoroacetophenone 

Downstream Products

• 1382223-62-2 N-(4-cyanophenyl)-2-(2,4-difluorophenyl)-2-oxoacetamide 
• 1160682-83-6 Methyl 7-bromo-3-(2,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate 
• 81593-35-3 5-(2,4-Difluoro-phenyl)-1-phenyl-imidazolidine-2,4-dione 

Relevant articles and documents

HERBICIDAL CINNOLINIUM COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

FLUORINE CONTAINING BIOACTIVE HETEROCYCLES PART III : SYNTHESIS OF SOME NEW FLUORINE CONTAINING PHENYLGLYOXALS AND 1,2,4-TRIAZINE DERIVATIVES

Some medicinally important new fluorine containing phenylglyoxals have been synthesized by selenium dioxide oxidation of appropriate fluorinated acetophenones and characterized by spectrum studies.The phenylglyoxals were treated with thiosemicarbazide to give corresponding thiosemicarbazones (III) which were cyclized, in situ, to yield 5-(fluorophenyl)-1,2,4-triazine-3(2H)-thiones.The 5-(4-fluorophenyl)-1,2,4-triazine-3-(2H)-thione (IV) undergoes nucleophilic displacement when refluxed with hydrazine hydrate to give corresponding 3-hydrazino-5-(4-fluorophenyl)-1,2,4-tria zine.The hydrazino derivative reacts with fluorinated 1,3-diketones, in glacial acetic acid yielding 5-(4-fluorophenyl)-3--1,2,4-triazines (VII).All synthesized compounds have been characterized on the basis of elemental analyses, ir, pmr and 19F nmr studies.

Fluorine Containing Bioactive Heterocycles. Part II. Synthesis of Some New Fluorine Containing Arylglyoxals, Their Hydrates and 1,5-Disubstituted Hydantoins

Eight new fluorine containing arylglyoxals have been synthesized by the oxidation of the active methyl group of fluorinated acetophenones by selenium dioxide in dioxan-water medium.The corresponding hydrates were obtained by dissolving arylglyoxals in minimum amounts of benzene and adding hot water.Seventeen new fluorine containing 1,5-disubstituted hydantoins were subsequently prepared by the condensation of these glyoxals with arylureas in ethanol and characterized by ir, pmr and mass spectral studies.Representative compounds have been screened for their possible anticonvulsant and analgesic activities.None of the compounds show significant analgesic activity.