Screening of simple carbohydrates as a renewable organocatalyst for the efficient construction of 1,3-benzoxazine scaffold
A convenient protocol for the two component preparation of 1,3-benzoxazines by using several protected and unprotected carbohydrate molecules as organocatalysts have been developed which is broadly applicable to condensation reaction between variety of Ma
Y?ld?r?m, Ayhan,Kaya, Yunus,G?ker, Mustafa
(2021/10/12)
Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines
A total of 42 benzyl- and pyridylmethyl amines were synthesized either by reductive amination of aromatic/heteroaromatic aldehydes with amines or by conjugate addition of amines to the cinnamates followed by reduction of the ester group with lithium aluminium hydride to the respective propanolamines. All the synthesized compounds were evaluated against both avirulent and virulent strains of Mycobacterium tuberculosis. Many of the compounds exhibited MIC as low as 1.56 μg/mL. Few of potent compounds were also evaluated against clinical isolates of MDR TB and found to be active at one or other concentrations with MIC as low as 3.12 μg/mL.
Reaction of 2-alkylaminomethylphenols with 4-nitrophenyl-bis(chloromethyl)phosphinate in toluene micellar solutions of polyethylene glycol-600 monolaurate
The effect of polyethylene glycol-600 monolaurate (PEG-ML) reversed micelles on the reaction of 2-alkylaminomethylphenols (AMP) with 4-nitrophenyl-bis(chloromethyl)phosphinate in toluene has been investigated.PEG-ML increases the observed rate constants o
Tishkova, E. P.,Shagidullina, R. A.,Kudryavtseva, L. A.,Ismaev, I. E.,Ivanov, B. E.
p. 2015 - 2019
(2007/10/02)
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