- Substituted Heterocyclic Mercaptosulfonamide Metalloprotease Inhibitors
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The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These compounds are designed to be potent selective inhibitors of matrix metalloproteinases (MMPs), including, for example, gelatinases, collagenases, matrilysins, metalloelastase, stromelysin, and membrane-type 1 matrix metalloproteinase. These inhibitors may be used for the control of physiological and pathological processes and disease conditions in which MMPs are believed to play significant functions.
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- Chemoenzymatic synthesis of (3S,4S)- and (3R,4R)-3-methoxy-4- methylaminopyrrolidine
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Facile chemoenzymatic enantioselective synthesis of (3S,4S)-3-methoxy-4- methylaminopyrrolidine, a key intermediate for a new quinolone antitumor compound AG-7352 has been described. This methodology illustrates the preparation of 3-azido-1-benzyloxycarbo
- Kamal, Ahmed,Shaik, Ahmad Ali,Sandbhor, Mahendra,Malik, M. Shaheer,Kaga, Harumi
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p. 8057 - 8059
(2007/10/03)
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