- Chemoselective conversion of aromatic epoxide and 1,2-diol to 1,3-dioxane derivatives with phenyltrimethylammonium tribromide in the presence of a catalytic amount of antimony(III) bromide
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trans-Stilbene oxide was oxidatively converted to 2-phenyl-1,3-dioxanes with phenyltrimethylammonium tribromide in the presence of various 1,3-diols and a catalytic amount of SbBr3 in DMSO at room temperature. Aromatic 1,2-diol, such as hydrobenzoin, was similarly converted to 2-aryl-1,3-dioxane derivatives under the same reaction conditions.
- Sayama, Shinsei
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- Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies
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Syntheses of 6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol 10 and 1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol 34 are described. The aryl phosphonic acid 14, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.
- Gonzalez-Bello, Concepcion,Abell, Chris,Leeper, Finian J.
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p. 1017 - 1024
(2007/10/03)
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