Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335)
C-Terminal carboxylic acid containing inhibitors of the NS3 protease are reported. A novel series of linear tripeptide inhibitors that are very potent and selective against the NS3 protease are described. A substantial contribution to the potency of these
Llinàs-Brunet, Montse,Bailey, Murray D.,Goudreau, Nathalie,Bhardwaj, Punit K.,Bordeleau, Josée,B?s, Michael,Bousquet, Yves,Cordingley, Michael G.,Duan, Jiamin,Forgione, Pat,Garneau, Michel,Ghiro, Elise,Gorys, Vida,Goulet, Sylvie,Halmos, Ted,Kawai, Stephen H.,Naud, Julie,Poupart, Marc-André,White, Peter W.
experimental part
p. 6466 - 6476
(2010/11/04)
CRYSTALLINE FORMS OF A 2-THIAZOLYL- 4-QUINOLINYL-OXY DERIVATIVE, A POTENT HCV INHIBITOR
This invention relates to novel crystalline forms of the following Compound (1), and the sodium salt thereof, and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection.
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Page/Page column 31
(2010/04/25)
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