cas 802904-66-1, 7-Methyl-5-[(3-piperazin-1-ylMethyl)-1,2,4-oxadiazol-5-yl-]-2-[4-(trifluoroMethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one Methanesulphonate | Articles data ｜lookchem

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802904-66-1

Articles about 802904-66-1Total 5 be found

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Development of scalable manufacturing routes to AZD1981. Application of the Semmler-Wolff aromatisation for synthesis of the indole-4-amide Core
A safe and efficient synthesis of AZD1981 is described in which the indole 4-amide core is formed by a Semmler-Wolff aromatisation of a cyclohexenone oxime fused to a pyrrole ring. The substrate was obtained via Paal-Knorr pyrrole synthesis, followed by i
Sulur, Manjunatha,Sharma, Parhalad,Ramakrishnan, Ravi,Naidu, Ravi,Merifield, Eric,Gill, Duncan M.,Clarke, Adrian M.,Thomson, Colin,Butters, Michael,Bachu, Sreekanth,Benison, Colin H.,Dokka, Nagaraju,Fong, Emily R.,Hose, David R. J.,Howell, Gareth P.,Mobberley, Siobhan E.,Morton, Simon C.,Mullen, Alexander K.,Rapai, Jayan,Tejas, Bharathi
p. 1746 - 1753
(2013/01/15)

Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981
Novel indole-3-thio-, 3-sulfonyl- and 3-oxy-aryl-1-acetic acids are reported which are potent, selective antagonists of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2). Optimization required maintenance of high
Luker, Tim,Bonnert, Roger,Brough, Steve,Cook, Anthony R.,Dickinson, Mark R.,Dougall, Iain,Logan, Chris,Mohammeda, Rukhsana T.,Paine, Stuart,Sanganee, Hitesh J.,Sargent, Carol,Schmidt, Jerzy A.,Teague, Simon,Thom, Stephen
p. 6288 - 6292
(2011/11/29)

INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF 4- (ACETYLAMINO) ) -3- [ (4-CHLORO-PHENYL) THIO] -2-METHYL-1H-INDOLE-1-ACETIC ACID
The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound of formula (I): X is =0, =N-0H or =N-OC(O)Me; Y is hydrogen, PhS- or p-ch
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(2011/02/24)

NOVEL PROCESS
The invention relates to a novel process for the preparation of substituted indoles which are useful as therapeutic agents.
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Page/Page column 12-13

(2008/06/13)

NOVEL SUBSTITUTED 3-SULFUR INDOLES
The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders.
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(2008/06/13)

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Chemical Properties

Boiling Point: 676.8±55.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
Solubility:insoluble in H2O; insoluble in EtOH; ≥19.8 mg/mL in DMSO
PKA: 4.06±0.10(Predicted)
PSA: 100.12000
LogP: 5.44680

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