- An Asymmetric Synthesis of Rosuvastatin Calcium
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A novel asymmetric synthesis of a (3R,5S)-dihydroxyhexanoic ester is described. The ester, which serves as the precursor for generating the side chain of rosuvastatin, is synthesized from d-glucose and subsequently coupled, under Wittig olefination condit
- Vempala, Naresh,Venkateswara Rao, Settipalli,Shree, Anireddy Jaya,Pradhan, Braja S.
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p. 4167 - 4174
(2016/11/26)
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- IMPROVED PRODUCTION OF ROSUVASTATIN CALCIUM SALT
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An improved process for manufacture of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, Formula (1), which is useful for the production of a pharmaceutical useful in the treatment of, inter alia, hypercholesterolemia, hyperlipoproteinemia and atherosclerosis, is described.
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