808162-99-4

Upstream product

• 289042-10-0 N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide 
• 808163-02-2 isopropyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 1364244-21-2 5-O-(triphenylmethyl)-3-deoxy-2-O-(methanesulfonyl)-D-glyceropent-2-enono-1,4-lactone 
• 1364244-19-8 5-O-(triphenylmethyl)-D-arabinono-1,4-lactone 
• 808163-04-4 isopropyl 2-[(4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 2782-09-4 D-arabinono-1,4-lactone 
• 1364244-34-7 (3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile 
• 1364244-32-5 5-O-(triphenylmethyl)-3-deoxy-1,2-anhydro-D-erythro-pentitol 

Downstream Products

• 917805-74-4 (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid-2-methylpropan-2-amine 

Relevant academic research and scientific papers

An Asymmetric Synthesis of Rosuvastatin Calcium

A novel asymmetric synthesis of a (3R,5S)-dihydroxyhexanoic ester is described. The ester, which serves as the precursor for generating the side chain of rosuvastatin, is synthesized from d-glucose and subsequently coupled, under Wittig olefination condit

IMPROVED PRODUCTION OF ROSUVASTATIN CALCIUM SALT

An improved process for manufacture of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, Formula (1), which is useful for the production of a pharmaceutical useful in the treatment of, inter alia, hypercholesterolemia, hyperlipoproteinemia and atherosclerosis, is described.