808737-53-3

Basic information

• Product Name: Oxazole, 4,4-diethyl-4,5-dihydro-5-methylene-2-phenyl- (9CI)
• Synonyms: Oxazole, 4,4-diethyl-4,5-dihydro-5-methylene-2-phenyl- (9CI)
• CAS NO: 808737-53-3
• Molecular Formula: C14H17NO
• Molecular Weight: 215.29088
• Product Categories: ETHYL
• Mol File: 808737-53-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Oxazole, 4,4-diethyl-4,5-dihydro-5-methylene-2-phenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 4,4-diethyl-4,5-dihydro-5-methylene-2-phenyl- (9CI)(808737-53-3)
• EPA Substance Registry System: Oxazole, 4,4-diethyl-4,5-dihydro-5-methylene-2-phenyl- (9CI)(808737-53-3)

Safety Data

• Hazardous Substances Data: 808737-53-3(Hazardous Substances Data)

Upstream product

• 3234-64-8 1,1-Diethylpropargylamine 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Silver-catalyzed preparation of oxazolines from N-propargylamides

Treatment of N-propargylamides with 5 mol% of silver hexafluoroantimonate results in the rapid formation of oxazolines in essentially quantitative yield. Georg Thieme Verlag Stuttgart.

Gold catalysis: Mild conditions for the synthesis of oxazoles from N-propargylcarboxamides and mechanistic aspects

(Chemical Equation Presented) 2,5-Disubstituted oxazoles are synthesized from the corresponding propargylcarboxamides under mild reaction conditions via homogeneous catalysis by AuCl3. While monitoring the conversion via 1H NMR spectroscopy, an intermediate 5-methylene-4,5-dihydrooxazole can be observed and accumulated up to 95%, being the first direct and catalytic preparative access to such alkylidene oxazolines. The intermediate was fully characterized and can be trapped at -25°C for several weeks. Deuteration experiments show a stereospecific mode of the two first steps of the reaction.