- Preparation method of formaldehyde-substituted aza-condensed ring compound
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The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.
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Paragraph 0117-0119
(2020/06/02)
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- PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES
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The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
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Page/Page column 56
(2012/09/22)
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- Amination of 2,6- and 2,7-Naphtyridine. An NMR Study on ?-Adducts of Heterocyclic Systems with Amide Ions
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A facile synthesis of 2,6-naphtyridine is described.Both 2,6- and 2,7-naphtyridine undergo with potassium amide under kinetically and thermodynamically controlled conditions ?-adduct formation at position 1.Chichibabin amination of 2,6-naphtyridine yields 1-amino-2,6-naphtyridine in 54percent yield.
- Haak, Henk J. W. van den,Plas, Henk C. van der,Veldhuizen, Beb van
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p. 1349 - 1352
(2007/10/02)
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