80935-78-0

Usage

Uses

Used in Organic Synthesis:
1-Chloro-[2,6]naphthyridine is used as a key intermediate in the synthesis of a variety of organic compounds. Its unique structure allows for the creation of new chemical entities with potential applications in various industries.
Used in Pharmaceutical Drug Preparation:
1-CHLORO-[2,6]NAPHTHYRIDINE plays a significant role in the preparation of pharmaceutical drugs, acting as a building block for the development of new medications. Its presence in the synthesis process can contribute to the creation of drugs with improved efficacy and reduced side effects.
Used in Medicinal Chemistry Research:
1-Chloro-[2,6]naphthyridine is employed as a research tool in medicinal chemistry, where it aids in the exploration of new drug candidates and the understanding of molecular interactions. Its involvement in research can lead to the discovery of novel therapeutic agents and a better comprehension of disease mechanisms.
Used in Scientific Research:
In the broader field of scientific research, 1-chloro-[2,6]naphthyridine serves as a valuable compound for studying chemical reactions and exploring the properties of various substances. Its application in research can contribute to advancements in multiple scientific disciplines.

InChI:InChI=1/C8H5ClN2/c9-8-7-2-3-10-5-6(7)1-4-11-8/h1-5H

Upstream product

• 80935-77-9 1,2-dihydro-2,6-naphthyridin-1-one 
• 80935-76-8 N,N-dimethylamino-2-(4-cyano-3-pyridyl)ethene 
• 7584-05-6 3-methyl-4-cyanopyridine 
• 1003-73-2 3-picoline-N-oxide 

Downstream Products

• 81044-13-5 1,5-diamino-2,6-naphthyridine 
• 80935-81-5 1-amino-2,6-naphtyridine 
• 253-50-9 2,6-naphthyridine 
• 848841-71-4 (4-isopropyl-phenyl)-[2,6]naphthyridin-1-yl-amine 
• 1398057-34-5 6-(2-fluoro-phenyl)-8-(6-oxy-[2,6]naphthyridin-1-yl)-pyrido[2,3-b]pyrazine 
• 1398056-99-9 5-[6-(2-fluoro-phenyl)-pyrido[2,3-b]pyrazin-8-yl]-[2,6]naphthyridin-1-ylamine 
• 1353967-79-9 2-(2-fluoro-phenyl)-4-(5-methoxy-[2,6]naphthyridin-1-yl)-[1,8]naphthyridine 
• 1353967-37-9 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine 
• 1353971-52-4 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine maleate 
• 1353970-74-7 2-(2-fluoro-phenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4-(6-oxy-[2,6]naphthyridin-1-yl)-[1,8]naphthyridine 
• 1353969-43-3 5-[2-(2-fluoro-phenyl)-6-(1-methyl-1H-pyrazol-4-yl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine 
• 1353968-69-0 2-(2-fluoro-phenyl)-4-(6-oxy-[2,6]naphthyridin-1-yl)-[1,8]naphthyridine 
• 1353968-47-4 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2H-[2,6]naphthyridin-1-one 
• 1353968-31-6 2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide 

Relevant academic research and scientific papers

Preparation method of formaldehyde-substituted aza-condensed ring compound

The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.

PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES

The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.

Amination of 2,6- and 2,7-Naphtyridine. An NMR Study on ?-Adducts of Heterocyclic Systems with Amide Ions

A facile synthesis of 2,6-naphtyridine is described.Both 2,6- and 2,7-naphtyridine undergo with potassium amide under kinetically and thermodynamically controlled conditions ?-adduct formation at position 1.Chichibabin amination of 2,6-naphtyridine yields 1-amino-2,6-naphtyridine in 54percent yield.