- Synthesis and QSAR studies of some novel disubstituted 1,2,4-triazoles as antimicrobial agents
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Disubstituted 1,2,4-triazoles 3a-k, 4a-k, and 6a-k have been synthesized from anthranilic acid and nicotinic acid, respectively, through a multi-step reaction sequence via their hydrazides. Synthesized compounds were evaluated for their in vitro antimicro
- Panda, Siva S.,Jain, Subhash C.
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- Synthesis and analgesic activity of new pyridine-based heterocyclic derivatives
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A series of new heterocyclic derivatives having a pyridine nucleus were synthesized. 4-(5-(2-Chlorophenyl)- 4H-1,2,4-triazol-3-yl)pyridine (7c) and 4-(5-(2- Nitrophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7d) presented the best analgesic profie of this series in hot-plate, tail-flick, and formalin-induced licking tests, which was partially prevented by pretreatment with mecamylamine, a nicotinic receptor antagonist. Springer Science+Business Media, LLC 2010.
- Nigade, Ganesh,Chavan, Pradeep,Deodhar, Meenakshi
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experimental part
p. 27 - 37
(2012/06/01)
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- Metallhydrazide, XIX. Addition bis(diethylaluminio)substituierter Amidrazone und Carbohydrazide an Nitrile
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Amidrazones and carbohydrazides react with two equivalents of triethylaluminium to give bis(diethylaluminio) derivatives 1 and 7, respectively.In contrast to the corresponding mono(diethylaluminio) derivatives or disodium salts, these are capable of addit
- Kauffmann, Thomas,Ban, Laszlo,Kuhlmann, Dieter
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p. 3684 - 3690
(2007/10/02)
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