Efficient synthesis of N-methylamides and amines via 4-(alkylamino)benzyl- N-methylamine as a new protecting group
4-(Alkylamino)benzyl-N-methylamine is a good protecting group for the synthesis of N-methylamides and amines. The N-debenzylation of N-methylamides and amines can be carried out selectively and efficiently under condition using trifluoroacetic acid (TFA).
Amino- and Amidomethylation of N,N-Dimethylaniline and Related Derivatives
The reaction of N,N-dimethylaniline (4) with N-methylenemorpholinium chloride (10g) affords 2,4-bis(morpholinomethyl)-N,N-dimethylaniline (11g) via 4-(morpholinomethyl)-N,N-dimethylaniline (9g) as an intermediate.From 4-(dimethylaminomethyl)- or 4-(pyrrol
Boehme, Horst,Bomke, Ulrich,Denis, Jean-Pierre
p. 40 - 47
(2007/10/02)
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