Microwave-induced Mannich reaction - Synthesis of some Mannich derivatives of p-aminophenol
Mono and bis substituted dialkylamino alkyl-p-aminophenol 3 are prepared by treating paracetamol 1 with formaldehyde and appropriate secondary amines followed by deacetylation using 6 M HCI in unmodified domestic microwave oven in unsealed borosil vessels
Mahesh,Perumal, R. Venkatesha
p. 1012 - 1014
(2007/10/03)
Anti-malaria active 10-H-indolo[3,2-b]quinoline-11-yl-amines. Part 1: Phenol-Mannich-bases of the amodiaquine and cycloquine type
The 11-chloro-quindoline derivatives 3 react with 4-aminophenol and the mono- and bis-phenol-Mannich-bases 6 to yield the 10 H-indolo[3,2-b]quinoline-11-ylamines 4 and 7. The amodiaquine analogue 7a as the best of all compounds shows a comparable activity with choroquine and inhibits a multiresistant Plasmodium falciparum strain at the same concentration. Compound 7e from the cycloquine-type was selected for an in vivo antitumor screening programme.
Gorlitzer,Stockmann,Walter
p. 231 - 235
(2007/10/02)
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