811456-29-8Relevant articles and documents
The identification of β-hydroxy carboxylic acids as selective MMP-12 inhibitors
Holmes, Ian P.,Gaines, Simon,Watson, Steve P.,Lorthioir, Olivier,Walker, Adam,Baddeley, Suzanne J.,Herbert, Shane,Egan, Danielle,Convery, Maire A.,Singh, Onkar M.P.,Gross, Jeffrey W.,Strelow, John M.,Smith, Robert H.,Amour, Augustin J.,Brown, David,Martin, Stephen L.
body text, p. 5760 - 5763 (2010/04/05)
A new class of selective MMP-12 inhibitors have been identified via high throughput screening. Crystallization with MMP-12 confirmed the mode of binding and allowed initial optimization to be carried out using classical structure based design.
5-Phenyl-Pentanoic Acid Derivatives as Matrix Metalloproteinase Inhibitors for the Treatment of Asthma and Other Diseases
-
Page/Page column 17-18, (2008/12/07)
The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alke
5-PHENYL-PENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS FOR THE TREATMENT OF ASTHMA AND OTHER DISEASES
-
Page/Page column 46-47, (2008/06/13)
The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alke
MATRIX METALLOPROTEINASE INHIBITORS
-
Page/Page column 21-22, (2008/06/13)
Compounds of Formula (I): Wherein: A represents bond, C1-6alkyl or CH=CH-C1-4alkyl; B represents bond, O, S, SO, SO2, CO, CR7R8, CO2R14, CONR14R15, N(COR14)(COR15), N(SO2R14)(COR15) or NR14R15; D represents bond, or C1-6alkyl; E represents substituted ary
MATRIX METALLOPROTEINASE INHIBITORS
-
Page 22; 23, (2010/02/09)
Compounds of formula (1): Wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents 0, S, NR5 or CR6 R7; Y represents CHOH, CHSH, NOR8, CNR8 or CNOR8