811803-25-5

Basic information

• Product Name: 1-(4-Aminophenyl)cyclobutanecarbonitrile
• Synonyms: 1-(4-Aminophenyl)cyclobutanecarbonitrile;1-(4-aminophenyl)cyclobutane-1-carbonitrile
• CAS NO: 811803-25-5
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.22638
• Mol File: 811803-25-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-Aminophenyl)cyclobutanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Aminophenyl)cyclobutanecarbonitrile(811803-25-5)
• EPA Substance Registry System: 1-(4-Aminophenyl)cyclobutanecarbonitrile(811803-25-5)

Safety Data

• Hazardous Substances Data: 811803-25-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(4-Aminophenyl)cyclobutanecarbonitrile is used as a key intermediate for the synthesis of pharmaceuticals due to its unique structure and reactivity. It aids in the development of new drugs by providing a foundation for further chemical modifications and enhancements.
Used in Organic Chemistry:
In the realm of organic chemistry, 1-(4-Aminophenyl)cyclobutanecarbonitrile is utilized as a building block for the creation of various organic compounds. Its cyclobutane ring and carbonitrile group offer distinct chemical properties that can be exploited in the synthesis of complex molecules.
Used in Chemical Synthesis:
1-(4-Aminophenyl)cyclobutanecarbonitrile is also employed as a versatile reagent in chemical synthesis, where its aminophenyl substituent can be further functionalized to produce a wide array of chemical products with diverse applications across different industries.

Upstream product

• 1236409-69-0 1-(4-nitrophenyl)cyclobutanecarbonitrile 
• 14377-68-5 1-phenylcyclobutanecarbonitrile 
• 555-21-5 4-Nitrophenylacetonitrile 

Downstream Products

• 1215017-74-5 1-[4-(2-morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidin-4-ylamino)-phenyl]-cyclobutanecarbonitrile 
• 1215103-19-7 1-[4-(4-cyclopentylamino-6-phenyl-pyrimidin-2-ylamino)-phenyl]-cyclobutanecarbonitrile 
• 1236409-70-3 ethyl 3-(4-(1-cyanocyclobutyl)phenylamino)propanoate 
• 1236410-58-4 ethyl 3-(2-cyano-N-(4-(1-cyanocyclobutyl)phenyl)acetamido)propanoate 
• 1236409-72-5 1-(4-(1-cyanocyclobutyl)phenyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile 
• 1492906-24-7 C₁₇H₁₄ClN₃O 
• 1236409-75-8 1-(4-(1-cyanocyclobutyl)phenyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile 
• 1492906-25-8 C₁₈H₁₅N₅O 
• 1236408-39-1 1-(4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-phenyl)cyclobutanecarbonitrile 

Relevant articles and documents

Pyridyl Radical Cation for C?H Amination of Arenes

Electron-transfer photocatalysis provides access to the elusive and unprecedented N-pyridyl radical cation from selected N-substituted pyridinium reagents. The resulting C(sp2)?H functionalization of (hetero)arenes furnishes versatile intermediates for the development of valuable aminated aryl scaffolds. Mechanistic studies that include the first spectroscopic evidence of a spin-trapped N-pyridyl radical adduct implicate SET-triggered, pseudo-mesolytic cleavage of the N?X pyridinium reagents mediated by visible light.

Exploratory Process Development of a Novel Diacylglycerol Acyltransferase-1 (DGAT-1) Inhibitor

A practical large-scale synthesis was developed for 1, a DGAT-1 inhibitor, involving an aza-Michael reaction, amidation, Dieckman cyclization, and conjugate addition of cyanamide followed by cyclization, to form the fused 4-amino-7,8-dihydropyrido[4,3-d]p

NOVEL HETEROCYCLIC COMPOUNDS AS GATA MODULATORS

Novel heterocyclic compounds, sstereoisomers thereof and/or pharmaceutically acceptable salts of formula (I) and its stereoisomers are provided. Additionally, methods of forming novel heterocyclic compounds, stereoisomers thereof and/or pharmaceutically a

4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES

The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.

Six membered amino-amide derivatives an angiogenisis inhibitors

The present invention relates to six membered amino-amide derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability, to their use as medicaments and to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans.