1236409-75-8

Upstream product

• 1236409-69-0 1-(4-nitrophenyl)cyclobutanecarbonitrile 
• 67-56-1 methanol 
• 1492906-24-7 C₁₇H₁₄ClN₃O 
• 1236409-72-5 1-(4-(1-cyanocyclobutyl)phenyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonitrile 
• 1236410-58-4 ethyl 3-(2-cyano-N-(4-(1-cyanocyclobutyl)phenyl)acetamido)propanoate 
• 555-21-5 4-Nitrophenylacetonitrile 
• 1236409-70-3 ethyl 3-(4-(1-cyanocyclobutyl)phenylamino)propanoate 
• 14377-68-5 1-phenylcyclobutanecarbonitrile 
• 811803-25-5 1-(4-aminophenyl)cyclobutanecarbonitrile 

Downstream Products

• 1236408-39-1 1-(4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-phenyl)cyclobutanecarbonitrile 

Relevant academic research and scientific papers

Exploratory Process Development of a Novel Diacylglycerol Acyltransferase-1 (DGAT-1) Inhibitor

A practical large-scale synthesis was developed for 1, a DGAT-1 inhibitor, involving an aza-Michael reaction, amidation, Dieckman cyclization, and conjugate addition of cyanamide followed by cyclization, to form the fused 4-amino-7,8-dihydropyrido[4,3-d]p

4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES

The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.