- 5(1-Piperazinyl(imidazo[2,1-b][1,3,5]benzothiadiazepines
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5-Diazacycloalkyl-imidazo[2,1-b][1,3,5]benzothiadiazepines, e.g. those of the formula STR1 the N-oxides and salts thereof are neuroleptic agents, lacking extrapyramidal side-effects.
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- Imidazole systems. I. Imidazo[2,1 b][1,3,5]benzothiadiazepine derivatives as potential antipsychotic agents
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Imidazo[2,1-b][1,3,5]benzothiadiazepine 3 constitutes a novel ring system, and its analogs 3a-i were synthesized to investigate their potential antipsychotic activity. The synthesis of the ring system was achieved by reaction of 2-aminophenylthioimidazoles 7 with phosgene or thiophosgene and by ring closure of the 1-[2-(2-imidazolyl)thiophenyliminocarbonyl]-1 piperazines 13. An efficient method for the conversion of thioureas 8, 12 to guanidine 3a via the corresponding cyanothioamidines 11, 14 was developed.
- Della Vecchia,Dellureficio,Kisis,Vlattas
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p. 1287 - 1294
(2007/10/02)
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