- Preparation method of methyl 4-amino-2-(2-ethylamino)butyrate dihydrochloride
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The invention discloses a preparation method of methyl 4-amino-2-(2-ethylamino)butyrate dihydrochloride. The methyl 4-amino-2-(2-ethylamino)butyrate dihydrochloride is prepared from tetrahydropyran-4-carboxylic acid used as an initial raw material through a ring opening bromination lactone formation ring, a hydrolysis reaction, a Ts reaction on a hydroxyl group, a methyl esterification reaction, an azidation reaction and a hydrogenation reduction reaction. The process route is slightly long, but the yield of every step approaches a theoretic yield, and azide can be purified only through one step; and the preparation method also has the advantages of small polarity and easy purification of the azide, convenience in operation, mild and easily-controlled reaction conditions, and low cost.
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Paragraph 0025; 0026; 0044; 0045; 0063; 0064
(2017/09/13)
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- Total Synthesis of Racemic Triptolide and Triptonide
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The total synthesis of (+/-)-triptolide (1) and (+/-)-triptonide (3) from tetralone 7 in 15 and 16 steps, respectively, is described.
- Lai, Chee Kong,Buckanin, Richard S.,Chen, Samuel J.,Zimmerman, Donna Frieze,Sher, Frank T.,Berchtold, Glenn A.
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p. 2364 - 2369
(2007/10/02)
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