81779-27-3

Basic information

• Product Name: 4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: 4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE;4-HYDROXY-1H-INDOLE-3-CARBOXALDEHYDE;4-Hydroxyindole-3-carboxaldehyde;4-Hydroxyindole-3-carboxaldehyde 98%;Zinc02563745;3-Formyl-4-hydroxy-1H-indole;1H-Indole-3-carboxaldehyde,4-hydroxy-;4-hydroxy-1H-indol-3-carbaldehyde
• CAS NO: 81779-27-3
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 81779-27-3.mol

Chemical Properties

• Melting Point: 198-200 °C
• Boiling Point: 426.28 °C at 760 mmHg
• Flash Point: 211.607 °C
• Appearance: /
• Density: 1.439 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.784
• Storage Temp.: Room temperature.
• PKA: 9.17±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE(81779-27-3)
• EPA Substance Registry System: 4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE(81779-27-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 81779-27-3(Hazardous Substances Data)

Usage

Uses

Used in Research and Experimental Settings:
4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE is used as a chemical compound for [application reason] in research and experimental settings. Its unique structure and properties make it a valuable component in various scientific investigations.
Used in Biochemical Processes:
4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE is used as a biochemical component for [application reason] in understanding and studying biochemical processes. Its presence in certain biological systems may contribute to the overall function and regulation of these processes.
Used in Pharmaceutical Development:
4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE is used as a potential pharmaceutical candidate for [application reason] in the development of new drugs and therapies. Its chemical properties and interactions with other molecules may offer insights into the design of novel therapeutic agents.
Used in Chemical Synthesis:
4-HYDROXY-1H-INDOLE-3-CARBALDEHYDE is used as a synthetic intermediate for [application reason] in the production of other chemical compounds. Its reactivity and functional groups make it a useful building block in the synthesis of more complex molecules.

InChI:InChI=1/C9H7NO2/c11-5-6-4-10-7-2-1-3-8(12)9(6)7/h1-5,10,12H

Upstream product

• 72527-73-2 4-iodo-indole-3-carboxaldehyde 
• 141692-10-6 (3-formylindol-4-yl)thallium (III) bistrifluoroacetate 
• 487-89-8 Indole-3-carboxaldehyde 
• 7042-71-9 4-benzyloxyindole-3-carbaldehyde 
• 2380-94-1 1H-indol-4-ol 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 404888-00-2 3-Formyl-4-hydroxyindole-1-carboxylic acid tert-butyl ester 
• 404887-98-5 7-bromo-4-hydroxyindole-3-carbaldehyde 
• 404888-04-6 4-benzyloxy-5-bromoindole-3-carbaldehyde 
• 404888-01-3 4-benzyloxy-1-tert-butoxycarbonylindole-3-carbaldehyde 
• 404888-03-5 4-benzyloxy-5-bromo-1-tert-butoxycarbonylindole-3-carbaldehyde 
• 405892-95-7 ((R)-1-phenylethyl)-(S)-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-ylamine 
• 405891-90-9 (2-benzenesulfonyl-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-yl)dimethylamine 
• 405893-10-9 (2-benzenesulfonyl-1-vinyl-2,7,8,9-tetrahydro-6-oxa-2-azabenzo[c,d]azulen-8-yl)dimethylamine 

Relevant articles and documents

A PRACTICAL AND SHORT ACCES TO 4-HYDROXY-3-INDOLECARBALDEHYDE AND ITS APPLICATION FOR THE SYNTHESIS OF PINDOLOL ANALOG

4-Hydroxy-3-indolecarbaldehyde (1) is produced simply by heating (3-formylindol-4-yl)thallium bis-trifluoroacetate with copper sulfate in N,N-dimethylformamide and water.Alkylation of 1 afforded predominantly 1-alkyl derivatives.Utilizing these results pindolol analog, 1-allyl-4-(3-t-butylamino-2-hydroxypropoxy)-3-indolecarbaldehyde was synthesized.

Tricylic indole compounds having affinity for serotonin receptor

Having an affinity against serotonine receptors, compound (I) shown below is useful as a therapeutic agent against various kinds of diseases of central nervous systems. (wherein R1 is hydrogen; R2 is hydrogen or lower alkyl; R3 is hydrogen, —COOR12 and so on; R4 is hydrogen, lower alkyl and so on, or R3 and R4 taken together may form ═O or ═S; R5 is hydrogen, or R3 and R5 taken together may form a bond; R6 is hydrogen, —COOR24 and so on; R7 is hydrogen, halogen, lower alkyl and so on; R8 is hydrogen, lower alkyl, cycloalkyl and so on; R9, R10 and R11 are each independently hydrogen, halogen, lower alkyl and so on)

TRICYCLIC INDOLE COMPOUNDS HAVING AFFINITY FOR SEROTONIN RECEPTOR

Having an affinity against serotonine receptors, compound (I) shown below is useful as a therapeutic agent against various kinds of diseases of central nervous systems. (wherein R1 is hydrogen ; R2 is hydrogen or lower alkyl ; R

Synthetic studies of psilocin analogs having either a formyl group or bromine atom at the 5- or 7-position.

Psilocin analogs having either a formyl group (9-12) or a bromine atom (13-18) at the 5- or 7-position have been prepared for the first time. Syntheses of 5- and 7-bromo derivatives of 4-hydroxy- (23, 24, 28) and 4-benzyloxyindole-3-carbaldehyde (19, 25,

Preparations of 1-hydroxyindole derivatives and their potent inhibitory activities on platelet aggregation

1-Hydroxymelatonin, 5-bromo- and 5,7-dibromo-1-hydroxytryptamine derivatives, 1,4-dihydroxy-5-nitroindole, 1-hydroxy-3-methylsulfinylmethylindole, and 5-acetyl-1,3,4,5-tetrahydro-1-hydroxypyrrolo[4,3,2-de]quinoline were synthesized for the first time. 1-Hydroxyindoles revealed potent inhibitory activities on platelet aggregation.

3-Cyano indoles as intermediates for cardioselective compounds

The present invention provides indole derivatives of the general formula: STR1 wherein R1 is a hydrogen atom, an aralkyl radical or a radical of the general formula: STR2 in which B is a reactive group or, together with R5, represent