404888-01-3 Usage
Uses
Used in Pharmaceutical Industry:
4-BENZYLOXY-1-BOC-3-INDOLECARBALDEHYDE is used as an intermediate in organic synthesis for the development of novel chemical compounds with potential therapeutic applications. Its unique molecular structure allows for the creation of biologically active molecules that can be further explored for their pharmacological properties and potential use in treating various diseases and conditions.
Used in Research and Development:
In the field of research and development, 4-BENZYLOXY-1-BOC-3-INDOLECARBALDEHYDE is utilized as a key component in the synthesis of new chemical entities. Its versatility and reactivity make it an essential tool for chemists and researchers working on the discovery and optimization of new drug candidates.
Used in Drug Design and Medicinal Chemistry:
4-BENZYLOXY-1-BOC-3-INDOLECARBALDEHYDE is employed as a building block in drug design and medicinal chemistry for the development of innovative pharmaceutical agents. Its unique structural features enable the design of molecules with improved pharmacokinetic and pharmacodynamic properties, enhancing their therapeutic potential.
Used in Chemical Synthesis:
In the realm of chemical synthesis, 4-BENZYLOXY-1-BOC-3-INDOLECARBALDEHYDE is used as a versatile starting material for the preparation of a wide range of chemical compounds. Its reactivity and functional groups make it suitable for various synthetic transformations, allowing for the creation of diverse chemical libraries for further exploration and application.
Check Digit Verification of cas no
The CAS Registry Mumber 404888-01-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,4,8,8 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 404888-01:
(8*4)+(7*0)+(6*4)+(5*8)+(4*8)+(3*8)+(2*0)+(1*1)=153
153 % 10 = 3
So 404888-01-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H21NO4/c1-21(2,3)26-20(24)22-12-16(13-23)19-17(22)10-7-11-18(19)25-14-15-8-5-4-6-9-15/h4-13H,14H2,1-3H3
404888-01-3Relevant academic research and scientific papers
Structure-guided design, synthesis, and biological evaluation of (2-(1 H-Indol-3-yl)-1 H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) methanone (ABI-231) analogues targeting the colchicine binding site in Tubulin
Wang, Qinghui,Arnst, Kinsie E.,Wang, Yuxi,Kumar, Gyanendra,Ma, Dejian,White, Stephen W.,Miller, Duane D.,Li, Wei,Li, Weimin
, p. 6734 - 6750 (2019/08/20)
ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. Guided by the crystal structure of ABI-231 in complex with tubulin, we performed structure-activity relationship studies around the 3-indole moiety that led to the discovery of several potent ABI-231 analogues, most notably 10ab and 10bb. The crystal structures of 10ab and 10bb in complex with tubulin confirmed their improved molecular interactions to the colchicine site. In vitro, biological studies showed that new ABI-231 analogues disrupt tubulin polymerization, promote microtubule fragmentation, and inhibit cancer cell migration. In vivo, analogue 10bb not only significantly inhibits primary tumor growth and decreases tumor metastasis in melanoma xenograft models but also shows a significant ability to overcome paclitaxel resistance in a taxane-resistant PC-3/TxR model. In addition, pharmacological screening suggested that 10bb has a low risk of potential off-target function.
Synthetic studies of psilocin analogs having either a formyl group or bromine atom at the 5- or 7-position.
Yamada, Fumio,Tamura, Mayumi,Hasegawa, Atsuko,Somei, Masanori
, p. 92 - 99 (2007/10/03)
Psilocin analogs having either a formyl group (9-12) or a bromine atom (13-18) at the 5- or 7-position have been prepared for the first time. Syntheses of 5- and 7-bromo derivatives of 4-hydroxy- (23, 24, 28) and 4-benzyloxyindole-3-carbaldehyde (19, 25,
