- Benzophenone derivatives useful in treating heart failure
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There is presented novel benzophenone derivatives of the formula STR1 wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or aminoacetyl, R3 is hydrogen or lower alkyl, R4 is hydrogen or halogen, R5 is hydrogen, amino, nitro or a group of the formula R3 --ON=C(R6)--and R6 is lower alkyl, with the proviso that R5 is a group of the formula H--ON=C(R6)--when R2 and R3 are both hydrogen, and their pharmaceutically acceptable acid addition salts. The compounds exhibit aldosterone-antagonistic properties and are accordingly suitable for the control or prevention of heart failure, hepatic ascites, primary aldosteronism and idiopathic hypertension.
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