Synthesis and structure-activity relationship of lipo-diterpenoid alkaloids with potential target of topoisomerase IIα for breast cancer treatment
Aconitine linoleate (11) isolated from the Aconitum sinchiangense W. T. Wang exhibited significant anti-tumor activity. Based on this, a series of novel lipo-diterpenoid alkaloids were synthesized and evaluated for their anticancer activities against MCF-
Preparation and application of alkaloid derivatives for reversing human anti-tumor drug resistance and resisting canine breast cancer
The invention relates to a method for synthesizing and preparing a series of 8-position long-chain fatty acyloxy-substituted diterpenoid alkaloid derivatives by taking natural diterpenoid alkaloid asa raw material. Experiments prove that the derivatives can be used as an anti-tumor preparation for efficiently reversing anti-tumor drug resistance, and can also be used as a preparation for resisting canine breast cancer.
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Paragraph 0037-0038
(2020/09/09)
Four new lipo-alkaloids from aconiti tuber
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Kitagawa,Yoshikawa,Chen,Kobayashi
p. 758 - 761
(2007/10/02)
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