Synthesis and structure-activity relationship of lipo-diterpenoid alkaloids with potential target of topoisomerase IIα for breast cancer treatment

DOI: 10.1016/j.bioorg.2021.104699

Source and publish data:

Bioorganic Chemistry (2021)

Update date:2022-08-04

Topics:

Authors:

Luan, Shangxian

Gao, Yingying

Liang, Xiaoxia

Zhang, Li

Yin, Lizi

He, Changliang

Liu, Shixi

Yin, Zhongqiong

Yue, Guizhou

Zou, Yuanfeng

Li, Lixia

Song, Xu

Lv, Cheng

Zhang, Wei

Jing, Bo

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Article abstract of DOI:10.1016/j.bioorg.2021.104699

Aconitine linoleate (11) isolated from the Aconitum sinchiangense W. T. Wang exhibited significant anti-tumor activity. Based on this, a series of novel lipo-diterpenoid alkaloids were synthesized and evaluated for their anticancer activities against MCF-

Full text of DOI:10.1016/j.bioorg.2021.104699

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