- AROMATIC-CATIONIC PEPTIDES CONJUGATED TO ANTIOXIDANTS AND THEIR USE IN TREATING COMPLEX REGIONAL PAIN SYNDROME
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Compositions comprising an antioxidant directed or indirectly conjugated to an aromatic-cationic peptide are provide. Said antioxidants are selected from TEMPO, Tro, PBN, AHDP, DBHP, Caf and Hem and may be conjugated to the aromatic-cationic peptide directly or indirectly via a linker to the N-terminus, C-terminus or a side chain of an amino acid residue of the aromatic-cationic peptide. In some embodiments, the aromatic-cationic peptide is 2',6'-Dmt-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2 or D-Arg-2',6'-Dmt-Lys-Phe-NH2. These conjugates have increased antioxidant activity as compared to the unconjugated aromatic-cationic peptide and have utility in treating complex regional pain syndrome.
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Paragraph 0218
(2018/02/03)
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- Spin-labeled dendrimers in EPR imaging with low molecular weight nitroxides
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Sixth-generation PAMAM dendrimers labeled with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO, shown schematically) have been synthesized and are shown to reoxidize EPR-silent hydroxylamines to EPR-active nitroxides. Therefore these dendrimers are potential TEMPO free radical life supporters for EPR imaging.
- Yordanov, Alexander T.,Yamada, Ken-Ichi,Krishna, Murali C.,Mitchell, James B.,Woller, Eric,Cloninger, Mary,Brechbiel, Martin W.
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p. 2690 - 2692
(2007/10/03)
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- INFLUENCE OF CHEMICAL STRUCTURE OF NITROXYL SPIN LABELS ON THEIR REDUCTION BY ASCORBIC ACID
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The influence of structure on the reduction of nitroxyl spin labels by ascorbic acid was examined using both piperidine and pyrrolidine nitroxyls.A five-fold molar excess of ascorbic acid and pH of 7.4 were used.The nitroxyl concentration was measured by electron spin resonance spectrometry.The five-membered (pyrrolidine) nitroxyls were more stable than the six-membered derivatives.Ring substituents also influenced the reaction.The anionic derivatives were more stable than the unionized compounds which, in turn, were more stable than the amines (cations at pH 7.4).
- Couet, W. R.,Brasch, R. C.,Sosnovsky, G.,Lukszo, J.,Prakash, I.,et. al.
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p. 1165 - 1172
(2007/10/02)
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- Synthesis and properties of some spin labeled long chain aliphatic acids
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We have synthesized and characterized a series of spin labeled aliphatic acids with variable chain lengths between the nitroxide radicals and the carboxylic group.These molecules should be of general utility in labeling a variety of substrates wich can react with the free carboxylic group.Variable temperature esr studies have been conducted with some of these molecules to characterize molecular motion as a function of solvent viscosity.
- Gala, D.,Schultz, R.,Kreilick, R.
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p. 710 - 715
(2007/10/02)
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