82048-29-1

Usage

InChI:InChI=1/C13H23N2O4/c1-12(2)7-9(8-13(3,4)15(12)19)14-10(16)5-6-11(17)18/h9H,5-8H2,1-4H3,(H,14,16)(H,17,18)

Upstream product

• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 
• 82032-23-3 C₁₅H₂₇N₂O₄ 
• 108-30-5 succinic acid anhydride 

Relevant academic research and scientific papers

AROMATIC-CATIONIC PEPTIDES CONJUGATED TO ANTIOXIDANTS AND THEIR USE IN TREATING COMPLEX REGIONAL PAIN SYNDROME

Compositions comprising an antioxidant directed or indirectly conjugated to an aromatic-cationic peptide are provide. Said antioxidants are selected from TEMPO, Tro, PBN, AHDP, DBHP, Caf and Hem and may be conjugated to the aromatic-cationic peptide directly or indirectly via a linker to the N-terminus, C-terminus or a side chain of an amino acid residue of the aromatic-cationic peptide. In some embodiments, the aromatic-cationic peptide is 2',6'-Dmt-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2 or D-Arg-2',6'-Dmt-Lys-Phe-NH2. These conjugates have increased antioxidant activity as compared to the unconjugated aromatic-cationic peptide and have utility in treating complex regional pain syndrome.

Spin-labeled dendrimers in EPR imaging with low molecular weight nitroxides

Sixth-generation PAMAM dendrimers labeled with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO, shown schematically) have been synthesized and are shown to reoxidize EPR-silent hydroxylamines to EPR-active nitroxides. Therefore these dendrimers are potential TEMPO free radical life supporters for EPR imaging.

INFLUENCE OF CHEMICAL STRUCTURE OF NITROXYL SPIN LABELS ON THEIR REDUCTION BY ASCORBIC ACID

The influence of structure on the reduction of nitroxyl spin labels by ascorbic acid was examined using both piperidine and pyrrolidine nitroxyls.A five-fold molar excess of ascorbic acid and pH of 7.4 were used.The nitroxyl concentration was measured by electron spin resonance spectrometry.The five-membered (pyrrolidine) nitroxyls were more stable than the six-membered derivatives.Ring substituents also influenced the reaction.The anionic derivatives were more stable than the unionized compounds which, in turn, were more stable than the amines (cations at pH 7.4).

Synthesis and properties of some spin labeled long chain aliphatic acids

We have synthesized and characterized a series of spin labeled aliphatic acids with variable chain lengths between the nitroxide radicals and the carboxylic group.These molecules should be of general utility in labeling a variety of substrates wich can react with the free carboxylic group.Variable temperature esr studies have been conducted with some of these molecules to characterize molecular motion as a function of solvent viscosity.