A new kind of acetylcholine esterase inhibitors and its preparation method and application (by machine translation)
The present invention provides a novel acetyl choline esterase inhibitor and its preparation method and application, in particular, the invention discloses a formula A shown with double AChE binding site of substituted acridine compound, and its preparation method and as acetylcholinesterase inhibitors. The preparation of the novel compounds of this invention demonstrate good inhibit acetylcholine esterase role, can be used as a preparation for treating and preventing HAMER (AD) application value. (by machine translation)
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Paragraph 0096; 0097
(2018/04/03)
REGIOSPECIFIC AND STEREOSPECIFIC SUBSTITUTION OF HYDROXYL IN ALIPHATIC ALCOHOLS BY HALOGEN
A new system containing triphenylphosphine and trichloro- and tribromoacetic ester makes it possible to substitute the hydroxyl group in alcohols by halogen.Regiospecific and stereospecific substitution of the hydroxyl by the halogen takes place as a result of the reaction of primary and secondary aliphatic alcohols and of 2-alkenols, susceptible to isomerization processes, with this system.
Matveeva, E. D.,Kurts, A. L.,Yalovskaya, A. I.,Nikishova, N. G.,Bundel', Yu. G.