822-49-1 Usage
Uses
Used in Chemical Synthesis:
Cyclopropanesulfonyl fluoride is used as a synthetic intermediate for the preparation of various organic compounds. Its cyclopropane ring and sulfonyl fluoride group provide a stable and reactive platform for the construction of complex molecules.
Used in Click Chemistry:
Cyclopropanesulfonyl fluoride is used as a connector in click chemistry for the assembly of -SO2linked small molecules with proteins or nucleic acids. This innovative approach through sulfates complements the use of amides and phosphate groups as linkers, offering new possibilities for the development of bioconjugates and other applications in chemical biology.
Check Digit Verification of cas no
The CAS Registry Mumber 822-49-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 822-49:
(5*8)+(4*2)+(3*2)+(2*4)+(1*9)=71
71 % 10 = 1
So 822-49-1 is a valid CAS Registry Number.
822-49-1Relevant articles and documents
Synthesis of Sulfonyl Fluorides from Sulfonamides
Pérez-Palau, Marina,Cornella, Josep
supporting information, p. 2497 - 2500 (2020/03/11)
A simple and practical synthesis of sulfonyl fluorides from sulfonamides is reported. The method capitalizes on the formation of the sulfonyl chloride by virtue of the reaction of Pyry-BF4 and MgCl2, and subsequent in situ conversion to the more robust and stable sulfonyl fluoride by the presence of KF. The mild conditions and high chemoselectivity of the protocol enable the late-stage formation of sulfonyl fluorides from densely functionalized molecules.
