154350-29-5

Basic information

• Product Name: Cyclopropanesulfonamide
• Synonyms: 4-METHANESULFONYLCHLOROBENZENE;4-CHLOROPHENYL METHYL SULPHONE;1-CHLORO-4-(METHANESULFONYL)-BENZENE;CYCLOPROPANE SULFONAMIDE;CYCLOPROPANESULFONYL AMIDE;TIMTEC-BB SBB006326;P-CHLOROPHENYL METHYL SULFONE;Cyclopropanesulfonamide (9CI)
• CAS NO: 154350-29-5
• Molecular Formula: C₃H₇NO₂S
• Molecular Weight: 121.16
• EINECS: 202-682-7
• Product Categories: SULFONAMIDE;sulfonyl compound;NULL
• Mol File: 154350-29-5.mol
• Article Data: 49

Chemical Properties

• Melting Point: 95-98 °C(lit.)
• Boiling Point: 263.091 °C at 760 mmHg
• Flash Point: 112.914 °C
• Appearance: White-like powder
• Density: 1.446 g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.69±0.20(Predicted)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: Cyclopropanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanesulfonamide(154350-29-5)
• EPA Substance Registry System: Cyclopropanesulfonamide(154350-29-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-38
• Safety Statements: 26-28-36/37/39
• WGK Germany: 3
• RTECS: WR5730000
• Hazardous Substances Data: 154350-29-5(Hazardous Substances Data)

Usage

Chemical Properties

Cyclopropanesulfonamide is a white solid. It is special antidote for the corn herbicide nicosulfuron, which increases the speed of corn herbicide degradation.

Uses

Cyclopropanesulfonamide is used as fine chemicals to the pharmaceutical, agrochemical, aroma, polymer and electronic industries.

InChI:InChI=1/C3H7NO2S/c4-7(5,6)3-1-2-3/h3H,1-2H2,(H2,4,5,6)

Upstream product

• 910209-21-1 sodium cyclopropylsulfinate 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 139631-62-2 cyclopropanesulfonyl chloride 
• 765-30-0 Cyclopropylamine 
• 681808-26-4 tert-butyl (cyclopropylsulfonyl)carbamate 
• 100-39-0 benzyl bromide 
• 630421-42-0 N-t-butyl-1-cyclopropylsulfonamide 

Downstream Products

• 914823-96-4 (3R,5S,8S)-8-butyl-N-((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)-7,10-dioxo-22-phenyl-2,11-dioxa-6,9,21-triazatetracyclo[15.6.2.1-3,6-.0-20,24-]hexacosa-1⁽²³⁾,17,19,21,24-pentaene-5-carboxamide 
• 1130320-40-9 C₂₆H₂₂F₂N₄O₅S 
• 1126423-67-3 C₂₅H₂₁F₂N₃O₄S 
• 1132610-91-3 cyclopropanesulfonic acid [1-(2-fluoro-benzyl)-3-(2-methoxy-pyridin-3-yl)-5-methyl-1H-pyrrolo[3,2-b]pyridine-2-carbonyl]-amide 
• 1033906-24-9 methyl 8-cyclohexyl-5-((cyclopropylsulfonyl)carbamoyl)-1,1-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylate 
• 923274-44-6 (1R,2R,4R)-4-(2-phenyl-quinazolin-4-yloxy)-cyclopentane-1,2-dicarboxylic acid 1-[((1R,2S)-1 cyclo-propanesulfonecarbonyl-2-vinylcyclopropyl)-amide] 2-(hex-5-enylmethylamide) 
• 146475-56-1 N-(p-tolyl)cyclopropanesulfonamide 
• 1343455-92-4 cyclopropanesulfonic acid [2-(2-fluoro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide 
• 1343456-03-0 cyclopropanesulfonic acid [2-(3-chloro-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide 
• 1343456-46-1 cyclopropanesulfonic acid [3,3-dimethyl-2-(3-methyl-5-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide 
• 1343456-59-6 Cyclopropanesulfonic acid [2-(3-methoxy-5-morpholin-4-yl-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide 
• 1343456-86-9 cyclopropanesulfonic acid [3,3-dimethyl-2-(4-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide 
• 1343457-34-0 cyclopropanesulfonic acid [2-(4'-isopropoxy-biphenyl-3-yl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl]-amide 
• 1343457-60-2 cyclopropanesulfonic acid (2-{3-[4-(2,4-dimethyl-phenyl)-piperazin-1-yl]-phenyl}-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl)-amide 

Relevant articles and documents

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl- O-(tert-butyl)hydroxylamine, t-BuONSO

Sulfonamides have played a defining role in the history of drug development and continue to be prevalent today. In particular, primary sulfonamides are common in marketed drugs. Here we describe the direct synthesis of these valuable compounds from organometallic reagents and a novel sulfinylamine reagent, t-BuONSO. A variety of (hetero)aryl and alkyl Grignard and organolithium reagents perform well in the reaction, providing primary sulfonamides in good to excellent yields in a convenient one-step process.

Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature

A novel, practical and highly efficient method for the construction of a variety of sulfonamides mediated by I2 was demonstrated. The reaction proceeds readily at room temperature using a variety of sodium sulfinates and amines or ammonia in water in a metal-, base-, ligand-, or additive-free protocol. Primary, secondary and tertiary sulfonamides were obtained in good to excellent yields with a broad range of functional group tolerability. This journal is