CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS
The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.
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Paragraph 0712-0715
(2020/03/29)
Synthesis and studies of photochromic properties of spirobenzopyran carboxy derivatives and their model compounds as potential markers
A number of photochromic markers, viz., spirobenzopyrans containing one or two active carboxy groups attached directly or through a spacer, as well as their model derivatives, were synthesized. The obtained compounds were characterized by instrumental methods of analysis. Spectrokinetic methods were used to study the behavior of the spirobenzopyran markers and the model derivatives in solutions in EtOH and toluene.
A novel dinuclear Schiff-base copper(II) complex modified electrode for ascorbic acid catalytic oxidation and determination
A new dinuclear copper salicylaldehyde-glycine Schiff-base complex [Cu 2(Sal-Gly)2(H2O)2] was synthesized and structurally characterized. [Cu2(Sal-Gly)2(H 2O)2] crysta
Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation
Proliferation of endothelial cells is critical for angiogenesis. We report orally available, in vivo active antiangiogenic agents which specifically inhibit endothelial cell proliferation. After identifying human umbilical vein endothelial cell (HUVEC) pr
An efficient one-pot synthesis of pyrrolo[4,3,2-ij]isoquinoline derivatives by a consecutive aza-wittig/electrocyclic ring-closure/intramolecular acylation process
Iminophosphorane, ethyl 5-ethoxycarbonyl-2-methoxy-α-[(triphenylphosphoranylidene)amino]cinn amate (4) reacts with aliphatic and aromatic isocyanates in toluene at 170°C to give directly the corresponding pyrrolo[4,3,2-ij]isoquinolines 8 in moderate yields.
Molina,Alajarin,Vidal
p. 293 - 296
(2007/10/02)
Synthesis and antimicrobial activity of hydroxy-isophthalaldehyde acid derivatives
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Piscopo,Diurno,Mazzoni,Cirino,Bolognese
p. 669 - 676
(2007/10/02)
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