- A preparation method of the emetic (by machine translation)
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The invention relates to the field of organic synthetic technology, in particular to a emetic preparation method, comprises the following steps: S1, 3 - methoxy methyl acrylic acid methyl ester preparation; S2, synthesis of [...]; S3, is the synthesis of third zuo; S4, and aldehyde; S5, closed-loop. This invention adopts the single melamine as the synthetic starting material, greatly reducing the cost, dicyandiamide as to effectively solve the problem of lack of raw material sources; solved in the prior art long reaction time, the reaction condition is sensitive, harsh, side reaction are numerous and complex, the use of expensive or difficult to prepare sodium of other reagents, reactions caused low overall yield, the product quality is poor, so that the synthesis process technology of the route is more stable, good reproducibility, high yield, the product quality is good, content can be up to 99.5%, the yield can reach 85.6%, has higher economic benefits. (by machine translation)
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Paragraph 0029; 0034; 0039; 0045; 0046; 0050; 0055; 0058
(2019/04/17)
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- An approach to aminonaphthoquinone ansamycins using a modified Danishefsky diene
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A robust and scalable synthesis of a novel, cyano-substituted Danishefsky-type diene and its use in the Diels-Alder reaction with various dienophiles is reported. The diene allows for the rapid construction of highly substituted aminonaphthoquinones that occur in numerous ansamycin antibiotics.
- Kuttruff, Christian A.,Geiger, Simon,Cakmak, Mesut,Mayer, Peter,Trauner, Dirk
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supporting information; experimental part
p. 1070 - 1073
(2012/04/04)
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- Stereoselective synthesis of pamamycin-607
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A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of β-alkoxyvinyl ketone intermediates and a β-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a β-alkoxymethacrylate intermediate.
- Jeong, Eun Jeong,Kang, Eun Joo,Sung, Lee Taek,Hong, Sung Kil,Lee, Eun
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p. 14655 - 14662
(2007/10/03)
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- Synthesis of racemic carbocyclic cyclopropanoid nucleoside analogues
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As further representatives of a novel class of carbocyclic nucleoside analogues (±)-cis- and (±)-trans-(2-hydroxymethylcyclopropyl)-uracil, -thymine, and -inosine were synthesized from the corresponding dialkyl 1,2-cyclopropane dicarboxylates.
- Csuk, Rene,Von Scholz, Yvonne
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p. 7193 - 7206
(2007/10/02)
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- Synthons for Polyketides: An Improved Synthesis of Methyl 3,3-Dialkoxy-2-methylpropanoates
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A versatile conversion of methyl methacrylate to methyl 3,3-dialkoxy-2-methylpropanoates proceeds via bromination, then treatment with excess sodium methoxide to yield methyl 3,3-dimethoxy-2-methylpropanoate, which can be transacetalized by treatment with alcohols under acid catalysis to yield the title compounds.Stereoselective chain-extension reactions of these compounds by aldol additions to the aldehydes derived from the ester group (C-1), or by titanium(IV)-mediated allylsilane additions to the acetal carbon (C-3), are examples of the potential utility of methyl 3,3-dialkoxy-2-methylpropanoates to natural products syntheses.
- Walkup, Robert D.,Obeyesekere, Nihal U.
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p. 607 - 611
(2007/10/02)
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- DICHLOROMETHYL ALKYL ETHERS AND SULFIDES IN THE REFORMATSKII REACTION
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A study was carried out on the reaction of dichloromethyl alkyl ethers and sulfides with α-brominated esters in the presence of zinc resulting in the formation of either α-alkyl-β-alkoxyacrylates (or α-alkyl-β-alkylthioacrylates) or α,α,α',α'-tetramethyl-β-alkoxyglutaric acid ( or α,α,α',α'-tetramethyl-β-alkylthioglutaric acid) depending on the structure of the starting bromoester.PMR and IR spectroscopy indicates the geometry of the α-alkyl-β-alkoxyacrylates and α-alkyl-β-alkylthioacrylates.
- Lapkin, I. I.,Fotin, V. V.
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p. 659 - 663
(2007/10/02)
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