82387-42-6

Basic information

• Product Name: methyl 3-methoxymethacrylate
• Synonyms: methyl 3-methoxymethacrylate;3-Methoxy-2-methylpropenoic acid methyl ester;Einecs 279-943-7
• CAS NO: 82387-42-6
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• EINECS: 279-943-7
• Mol File: 82387-42-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 166.8°Cat760mmHg
• Flash Point: 59°C
• Appearance: /
• Density: 0.994g/cm³
• Vapor Pressure: 1.75mmHg at 25°C
• Refractive Index: 1.422
• CAS DataBase Reference: methyl 3-methoxymethacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-methoxymethacrylate(82387-42-6)
• EPA Substance Registry System: methyl 3-methoxymethacrylate(82387-42-6)

Safety Data

• Hazardous Substances Data: 82387-42-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H10O3/c1-5(4-8-2)6(7)9-3/h4H,1-3H3/b5-4+

Upstream product

• 3673-79-8 methyl 2,3-dibromoisobutyrate 
• 124-41-4 sodium methylate 
• 80-62-6 methacrylic acid methyl ester 
• 67-56-1 methanol 
• 5445-17-0 Methyl 2-bromopropionate 
• 4885-02-3 Dichloromethyl methyl ether 
• 76526-43-7 methyl 3,3-dimethoxy-2-methylpropionate 

Downstream Products

• 82387-35-7 (Z)-3-(3-Benzyl-ureido)-2-methyl-acrylic acid methyl ester 
• 82387-34-6 (E)-3-(3-Benzyl-ureido)-2-methyl-acrylic acid methyl ester 
• 56674-63-6 2-methyl-3-methoxy-2-propen-1-oic acid 
• 482626-53-9 C₄₄H₅₀O₁₁S 
• 27276-77-3 2-benzylamino-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one 
• 76526-63-1 4-Methoxy-3-methyl-5-phenylsulfanyl-5-propyl-5H-furan-2-one 
• 76526-62-0 5-Isopropyl-4-methoxy-3-methyl-5-phenylsulfanyl-5H-furan-2-one 
• 76526-61-9 5-Ethyl-4-methoxy-3-methyl-5-phenylsulfanyl-5H-furan-2-one 
• 482626-55-1 (R)-2-{(2R,5S)-5-[(1R,2R,3R,4R)-2-Benzyloxy-1,3-dimethyl-4-((E)-3-oxo-hex-1-enyloxy)-6-(toluene-4-sulfonyloxy)-hexyl]-tetrahydro-furan-2-yl}-propionic acid methyl ester 
• 374752-89-3 C₃₇H₄₃IO₈ 
• 374752-91-7 C₃₇H₄₄O₈ 
• 374752-92-8 (R)-2-{(2R,5S)-5-[(1R,2S,3R,4R)-2-Benzyloxy-4-hydroxy-1,3-dimethyl-6-(toluene-4-sulfonyloxy)-hexyl]-tetrahydro-furan-2-yl}-propionic acid methyl ester 
• 374752-93-9 (R)-2-{(2R,5S)-5-[(1R,2R,3R,4R)-2-Benzyloxy-6-iodo-1,3-dimethyl-4-((E)-3-oxo-hex-1-enyloxy)-hexyl]-tetrahydro-furan-2-yl}-propionic acid methyl ester 
• 374752-94-0 (R)-2-((2R,5S)-5-{(1R,2S,3R)-2-Benzyloxy-1-methyl-3-[(2R,5S)-5-(2-oxo-pentyl)-tetrahydro-furan-2-yl]-butyl}-tetrahydro-furan-2-yl)-propionic acid methyl ester 

Relevant articles and documents

A preparation method of the emetic (by machine translation)

The invention relates to the field of organic synthetic technology, in particular to a emetic preparation method, comprises the following steps: S1, 3 - methoxy methyl acrylic acid methyl ester preparation; S2, synthesis of [...]; S3, is the synthesis of third zuo; S4, and aldehyde; S5, closed-loop. This invention adopts the single melamine as the synthetic starting material, greatly reducing the cost, dicyandiamide as to effectively solve the problem of lack of raw material sources; solved in the prior art long reaction time, the reaction condition is sensitive, harsh, side reaction are numerous and complex, the use of expensive or difficult to prepare sodium of other reagents, reactions caused low overall yield, the product quality is poor, so that the synthesis process technology of the route is more stable, good reproducibility, high yield, the product quality is good, content can be up to 99.5%, the yield can reach 85.6%, has higher economic benefits. (by machine translation)

Stereoselective synthesis of pamamycin-607

A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of β-alkoxyvinyl ketone intermediates and a β-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a β-alkoxymethacrylate intermediate.

Synthons for Polyketides: An Improved Synthesis of Methyl 3,3-Dialkoxy-2-methylpropanoates

A versatile conversion of methyl methacrylate to methyl 3,3-dialkoxy-2-methylpropanoates proceeds via bromination, then treatment with excess sodium methoxide to yield methyl 3,3-dimethoxy-2-methylpropanoate, which can be transacetalized by treatment with alcohols under acid catalysis to yield the title compounds.Stereoselective chain-extension reactions of these compounds by aldol additions to the aldehydes derived from the ester group (C-1), or by titanium(IV)-mediated allylsilane additions to the acetal carbon (C-3), are examples of the potential utility of methyl 3,3-dialkoxy-2-methylpropanoates to natural products syntheses.