824960-64-7

Basic information

• Product Name: JWH -210
• Synonyms: JWH -210;1-Pentyl-3-(4-ethyl-1-naphthoyl)indole;JWH-210,1-Pentyl-3-(4-ethyl-1-naphthoyl)indole;JWH 210 7-ethylnaphthyl isomer;(7-ethylnaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
• CAS NO: 824960-64-7
• Molecular Formula: C26H27NO
• Molecular Weight: 369.49868
• Product Categories: Chemical for Research
• Mol File: 824960-64-7.mol

Chemical Properties

• Boiling Point: 555.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• CAS DataBase Reference: JWH -210(CAS DataBase Reference)
• NIST Chemistry Reference: JWH -210(824960-64-7)
• EPA Substance Registry System: JWH -210(824960-64-7)

Safety Data

• Hazardous Substances Data: 824960-64-7(Hazardous Substances Data)

Usage

Uses

Used in Forensic Applications:
JWH-210 is used as a forensic tool for the identification and analysis of synthetic cannabinoids in herbal blends and other substances. Its presence can help in determining the composition of these blends and aid in the investigation of drug-related cases.
Used in Research and Development:
JWH-210 is utilized in research and development for the study of its cannabimimetic properties and potential applications in the development of new drugs and therapies. This can include the investigation of its effects on the endocannabinoid system and its potential use in treating various medical conditions.
Used in Drug Testing and Analysis:
JWH-210 is employed in drug testing and analysis to detect the presence of synthetic cannabinoids in biological samples, such as blood, urine, or hair. This can be crucial in cases of drug abuse, overdose, or for monitoring patients undergoing treatment for substance abuse disorders.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, JWH-210 could potentially be used in the pharmaceutical industry for the development of new drugs targeting the endocannabinoid system. This could include the creation of medications for pain management, anxiety, and other conditions that may benefit from cannabinoid-based therapies. However, further research and development would be required to explore these potential applications.

Upstream product

• 59529-21-4 1-pentyl-1H-indole 
• 824430-41-3 7-ethyl-1-naphthoic acid 
• 939-27-5 2-ethylnaphthalene 
• 105523-17-9 1-acetyl-7-ethylnaphthalene 

Relevant articles and documents

CB2-selective cannabinoid analogues

Cannabinoid analogues that exhibit specificity for the CB2 cannabinoid receptor are provided. The analogues are 1-methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Δ8-tetrahydrocannabinols and 1-alkyl-3(1-naphthoyl)indoles. The compounds are useful for the treatment of pain (especially pain resulting from inflammation) and cancer (especially glioma tumors).

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists

The synthesis and pharmacology of 47 1-alkyl-3-(1-naphthoyl)indoles (R = C3H7 and C5H11, R′ = H and CH3) is described. Naphthoyl substituents include 4- and 7-alkyl groups, plus 2, 4, 6, and 7-methoxy groups. Three of these compounds are highly selective CB2 receptor agonists. In an effort to improve indole-based CB2 cannabinoid receptor ligands and also to develop SAR for both the CB1 and CB2 receptors, 47 indole derivatives were prepared and their CB1 and CB2 receptor affinities were determined. The indole derivatives include 1-propyl- and 1-pentyl-3-(1- naphthoyl)indoles both with and without a 2-methyl substituent. Naphthoyl substituents include 4- and 7-alkyl groups as well as 2-, 4-, 6-, 7-methoxy and 4-ethoxy groups. The effects of these substituents on receptor affinities are discussed and structure-activity relationships are presented. In the course of this work three new highly selective CB2 receptor agonists were identified, 1-propyl-3-(4-methyl-1-naphthoylindole (JWH-120), 1-propyl-2-methyl-3-(6-methoxy-1-naphthoylindole (JWH-151), and 1-pentyl-3-(2-methoxy-1-naphthoylindole (JWH-267). GTPγS assays indicated that JWH-151 is a full agonist at CB2, while JWH-120 and JWH-267 are partial agonists. Molecular modeling and receptor docking studies were carried out on a set of 3-(4-propyl-1-naphthoyl)indoles, a set of 3-(6-methoxy-1- naphthoyl)indoles and the pair of N-pentyl-3-(2-methoxy-1-naphthoyl)indoles. Docking studies indicated that the CB1 receptor affinities of these compounds were consistent with their aromatic stacking interactions in the aromatic microdomain of the CB1 receptor.