- ANDROGEN RECEPTOR MODULATING COMPOUNDS
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Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.
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Page/Page column 136
(2011/05/11)
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- HYDRAZONE DERIVATIVE
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A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof
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Page/Page column 47
(2010/11/08)
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- C-2 basically substituted thiazoles with H2-antagonistic activity/21st Comm.: H2-antihistamines
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In studies on structure-activity relationships of histamine H2-receptor antagonists, C-2 basically substituted thiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium and on the histamine stimulated acid secretion of the anaesthetized rat. As a basic substituent the dimethylaminomethyl group is especially suitable, while cyclic guanidines lead to lower H2-antagonistic activity.
- Trumm,Sattler,Postius,Szelenyi,Schunack
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p. 573 - 577
(2007/10/02)
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- 2-[2-(2-AMINOALKYL-4-THIAZOLYLMETHYLTHIO)ALKYL]-AMINO-5-SUBSTITUTED-4-PYRIMIDONES
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2-2-(2-aminoalkyl-4-thiazolylmethylthio)-alkylene!amino-5-aromatic-substitute d alkylene-4-pyrimidones and related compounds, H. sub.2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.
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- N-THIAZOLYLMETHYLTHIOALKYL-N`-ALKENYL (OR ALKYNYL)GUANIDINES AND RELATED COMPOUNDS
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N-alkenyl (or N-alkynyl)-N'-2-(aminoalkyl)-4-thiazolylmethylthio!alkylguanidines, thioureas, ethenediamines and related compounds, H 2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.
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- N-METHYL-N'-2-([(2-DIMETHYLAMINOMETHYL)-4-THIAZOLYL]METHYLTHIO)ETHYL 2-NITRO-1,1-ETHENEDIAMINE
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N-Alkyl-N'-( 2-(aminoalkyl)-4-thiazolylmethyl!thioalkyl) guanidines, thioureas, ethenediamines and related compounds, H 2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.
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- N-THIAZOLYLMETHYLTHIOALKYL-N'ALKYLAMIDINES AND RELATED COMPOUNDS
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N-alkyl-N'-(2-aminoalkyl-4-thiazolylmethylthio)alkyl guanidines, thioureas, ethenediamines and related compounds, H 2-receptor antagonists, useful in inhibiting gastric acid secretion in mammals.
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